Abstract
The current debate on synthetic biology and artificial life is often seen as a theoretical exercise with not much basis in reality. So far, laboratories have not made many advances in creating completely new life forms, but at the same time, the increasing technical potential to radically change the genome of existing life forms has escaped broader public attention.
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References
Annaluru, N., Muller, H., Mitchell, L.A., Ramalingam, S., Stracquadanio, G., Richardson, S.M., … Chandrasegaran, S. (2014). Total Synthesis of a Functional Designer Eukaryotic Chromosome. Science, 344(6179), 55–58. doi: 10.1126/science.1249252.
Baker, M. (2014). Gene editing at CRISPR speed. Nature Biotechnology, 32(4), 309–312.
Bauer-Panskus, A., Breckling, B., Hamberger, S., & Then, C. (2013). Cultivation-independent establishment of genetically engineered plants in natural populations: current evidence and implications for EU regulation. Environmental Sciences Europe, 25(1), 34. doi: 10.1186/2190–4715-25–34.
Bortesi, L., & Fischer, R. (2014). The CRISPR/Cas9 system for plant genome editing and beyond. Biotechnology Advances, 33(1), 41–52. doi: 10.1016/j.biotechadv.2014.12.006.
Carr, P.A., Wang, H.H., Sterling, B., Isaacs, F.J., Lajoie, M.J., Xu, G., Church, G.M., & Jacobson, J.M. (2012). Enhanced multiplex genome engineering through co-operative oligonucleotide co-selection. Nucleic Acids Research. 40(17), e132. doi: 10.1093/nar/gks455.
Church, G., & Regis, E. (2012). Regenesis: How Synthetic Biology Will Reinvent Nature and Ourselves. New York: Basic Books.
Fu, Y., Foden, J.A., Khayter, C., Maeder, M.L., Reyon, D., Joung, J.K., & Sander, J.D. (2013). High-frequency off-target mutagenesis induced by CRISPR-Cas nucleases in human cells. Nature Biotechnology, 31(9), 822–826.
Gantz, V.M., & Bier, E. (2015). The mutagenic chain reaction: A method for converting heterozygous to homozygous mutations. Science, 348(6233), 442–444.
Gibson, D.G., Glass, J.I., Lartigue, C., Noskov, V.N., Chuang, R.Y., Algire, M.A., … Venter, J.C. (2010). Creation of a bacterial cell controlled by a chemically synthesized genome. Science, 329(5987), 52–56.
Glass, J.T., Smith, H.O., Hutchinson, C.A., Alperovich, N.Y., & Assad-Garcia, N. (2007). International Patent WO2007/047148. Washington, D.C.: World Intellectual Property Organization.
Hai, T., Teng, F., Guo, R., Li, W., & Zhou, Q. (2014). One-step generation of knockout pigs by zygote injection of CRISPR/Cas system. Cell research, 24(3), 372–375.
Intrexon (2013). Intrexon Corporation Raises $150 Million for Synthetic Biology Initiatives. Intrexon Corporation. http://investors.dna.com/phoenix.zhtml?c=249599&p=irol-newsArticle&ID=1844278&highlight=.Accessed: 30 April 2015.
JCVI (2010). J. Craig Venter Institute. First Self-Replicating Synthetic Bacterial Cell [Press Release]. http://www.jcvi.org/cms/press/press-releases/full-text/article/first-self-replicating-synthetic-bacterial-cell-constructed-by-j-craig-venter-institute-researcher/. Accessed: 28 April 2015.
Lusser, M., Parisi, C., Plan, D., & Rodríguez-Cerezo, E. (2011). New plant breeding techniques. Stateof-the-art and prospects for commercial development.(= JRC Scientific and Technical Reports/EUR 24760 EN).
Pauwels, K., Podevin, N., Breyer, D., Carroll, D., & Herman, P. (2014). Engineering nucleases for gene targeting: safety and regulatory considerations. New Biotechnology, 31(1), 18–27.
Popper, K. (1992). In search of a better world. London: Routledge.
Sander, J.D., & Joung, J.K. (2014). CRISPR-Cas systems for editing, regulating and targeting genomes. Nature Biotechnology, 32(4), 347–355.
Segal, D.J., & Meckler, J.F. (2013). Genome engineering at the dawn of the golden age. Annual Review of Genomics and Human Genetics, 14, 135–158.
Tan, W., Carlson, D.F., Lancto, C.A., Garbe, J.R., Webster, D.A., Hackett, P.B., & Fahrenkrug, S.C. (2013). Efficient nonmeiotic allele introgression in livestock using custom endonucleases. Proceedings of the National Academy of Sciences, 110(41), 16526–16531.
Then, C. (2015). Handbuch Agrogentechnik. München: Oekom Verlag.
Vogel, B. (2012). Neue Pflanzenzuchtverfahren – Grundlagen für die Klärung offener Fragen bei der rechtlichen Regulierung neuer Pflanzenzuchtverfahren. Bundesamt für Umwelt
(BAFU), Sektion Biotechnologie, Bern; Baudirektion des Kantons Zürich, Amt für Abfall, Wasser, Energie und Luft (AWEL), Sektion Biosicherheit (SBS). www.awel.zh.ch/internet/baudirektion/awel/de/biosicherheit_neobiota/veroeffentlichungen/_jcr_content/contentPar/publication_2/publicationitems/titel_wird_aus_dam_e_0/download.spooler.download.1372927394124.pdf/Schlussbericht_NeuePflanzenzuchtverfahren_DEZ2012.pdf. Accessed: 30 April 2015.
Vogel, G. (2015). Embryo engineering alarm, researchers call for restraint in genome editing. Science, 347(6228), 1301. doi: 10.1126/science.347.6228.1301.
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Then, C. (2016). Synthetic Genome Technologies. In: Boldt, J. (eds) Synthetic Biology. Technikzukünfte, Wissenschaft und Gesellschaft / Futures of Technology, Science and Society. Springer VS, Wiesbaden. https://doi.org/10.1007/978-3-658-10988-2_12
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DOI: https://doi.org/10.1007/978-3-658-10988-2_12
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