Toxicological Evaluation of the Anticholinesterase Agents
The toxicology of the anticholinesterase (anti-ChE) agents has received a great deal of attention during the last twenty years. The intense interest exhibited in this aspect of their biological actions has been stimulated by consideration of their potential value as chemical warfare agents and to a greater extent in recent years by their established value and widespread use as agricultural insecticides. The latter practical application of these compounds has prompted investigation of their toxicity to various laboratory animals as a means of evaluating the possible human health hazards to those engaged in the manufacture and use of these compounds and the consumption of food upon which they have been used. The anti-ChE agents have limited medicinal uses. By far the most important use of these agents at the present time, from the standpoint of both the quantities involved and benefits derived, is for the eradication of destructive insects. High toxicity to insects is thus an essential requirement for anti-ChE agents.
KeywordsOrganophosphorus Compound Chemical Warfare Agent Organophosphorus Insecticide Mammalian Toxicity Carbamic Acid
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