Abstract
The toxicology of the anticholinesterase (anti-ChE) agents has received a great deal of attention during the last twenty years. The intense interest exhibited in this aspect of their biological actions has been stimulated by consideration of their potential value as chemical warfare agents and to a greater extent in recent years by their established value and widespread use as agricultural insecticides. The latter practical application of these compounds has prompted investigation of their toxicity to various laboratory animals as a means of evaluating the possible human health hazards to those engaged in the manufacture and use of these compounds and the consumption of food upon which they have been used. The anti-ChE agents have limited medicinal uses. By far the most important use of these agents at the present time, from the standpoint of both the quantities involved and benefits derived, is for the eradication of destructive insects. High toxicity to insects is thus an essential requirement for anti-ChE agents.
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Literature
Augustinsson, K. B.: Mintacol (diethyl p-nitrophenyl phosphate). Svensk farm. T. 57, 261 to 267 (1953).
Aldridge, W. N.: The differentiation of true and pseudocholinesterase by organophosphorus compounds. Biochem. J. 53, 62–67 (1953).
Aldridge, W. N., and J. M. Barnes: Some problems in assessing the toxicity of the “organophosphorus” insecticides towards mammals. Nature (Lond.) 169, 345–352 (1952).
Bagdon, R. E., and K. P. DuBois: Pharmacologic effects of Chlorthion, Malathion and tetrapropyl dithionopyrophosphate in mammals. Arch. int. Pharmacodyn. 103, 192–199 (1955).
Barnes, J. M., and F. A. Denz: The reaction of rats to diets containing octamethyl pyrophosphoramide (Schradan) and 0,0-diethyl-S-ethylmercaptoethanol thiophosphate (“Systox”). Brit. J. industr. Med. 11, 11–19 (1954).
Bidstrup, P. L., J. A. Bonnell and A. G. Beckett: Paralysis following poisoning by a new organic phosphorus insecticide (Mipafox). Brit. med. J. 1, 1068–1072 (1953).
Bombinski, T. J., and K. P. Dubois: Toxicity and mechanism of action of Di-Syston. A.M. A. Arch. industr. Hlth 17, 192–199 (1958).
Brauer, R. W.: Inhibition of the cholinesterase activity of human blood plasma and erythrocyte stromata by alkylated phosphorus compounds. J. Pharmacol. exp. Ther. 92, 162–172 (1948).
Bruce, R. B., J. W. Howard and J. R. Elsea: Toxicity of 0,0-diethyl 0-(2-isopropyl6-methyl-4-pyrimidyl phosphorothioate (Diazinon). J. Agric. food Chem. 3, 1017–1021 (1955).
Burgen, A. S. V., C. A. Keele and D. Slome: Pharmacological actions of tetraethylpyro-phosphate and hexaethyltetraphosphate. J. Pharmacol. exp. Ther. 96, 396–409 (1949).
Casida, J. E.: Metabolism of organophosphorus insecticides in relation their antiesterase activity, stability, and residual properties. J. Agric. food Chem. 4, 772–785 (1956).
Casida, J. E., T. C. Allen and M. A. Stahmann: Mammalian conversion of octamethyl pyrophosphoramide to a toxic phosphoramide-N-oxide. J. biol. Chem. 210, 607–616 (1954).
Cook, J. W., J. R. Blake and M. W. Wu Llams: The enzymic hydrolysis of Malathion and its inhibition by EPN and other organic phosphorus compounds. J. Ass. Off. Agric. Chem. 40, 664 665 (1957).
Davies, D. R.: Cholinesterases and the mode of action of some anticholinesterases. J. Pharmacol. 6, 1–26 (1954).
Davison, A. N.: The conversion of Schradan (OMPA) and Parathion into inhibitors of cholinesterase by mammalian liver. Biochem. J. 61, 203–209 (1955).
Deichmann, W. B., and K. Lampe: Dipterex: Its pharmacologic action and an appraisal of the hazard associated with its use. Univ. Miami School med. Bull. 9, 7–12 (1955).
Deichmann, W. B., W. Pugliese and J. Cassidy: Effects of dimethyl and diethyl paranitrophenyl thio- phosphate on experimental animals. A. M. A. Arch. industr. Hyg. 5, 44–51 (1952).
Deichmann, W. B., and R. Rakoczy: Toxicity and mechanism of action of Systox. A. M. A. Arch. industr. 111th 11, 324–331 (1955).
Diggle, W. M., and J. C. Gage: Cholinesterase inhibition in vivo by 0,0-diethyl 0-p-nitrophenyl thiophosphate (Parathion, E 605). Biochem. J. 49, 491–494 (1951).
Distefano, V., L. Hurwitz, W. F. Neuman and H. C. Hodge: Coramine (Nikethamide) as adjuvant to atropine in treatment of poisoning by EPN (ethyl p-nitrophenyl thionobenzenephosphonate). Proc. Soc. exp. Biol. (N. Y.) 78, 712–713 (1951).
Doull, J., and K. P. Dubois: Toxicity and anticholinesterase action of tetra-n-propyl dithionopyrophosphate. J. Pharmacol. exp. Ther. 106, 382 (1952).
DuBois, K. P.: Potentiation of the toxicity of organophosphorus compounds. Advances in Pest Control Research, Vol. 4. In press. New York: Interscience Publishers 1961.
DuBois, K. P., and K. W. Cochran: Inhibition of cholinesterase by dimethylamino fluorophosphate. Fed. Proc. 10, 292 (1951).
DuBois, K. P., and J. M. CooN: Toxicology of organic phosphorus-containing insecticides to mammals. Arch. industr. Hyg. 6, 9–13 (1952).
DuBois, K. P., and G. J. Cotter: Studies on the toxicity and mechanism of action of Dipterex. A. M. A. Arch. industr. Hlth 11, 53–60 (1955).
DuBois, K. P. J. DoULL and J. M. COON: Toxicity and mechanism of action of p-nitro-phenyl-diethylthionophosphate (E 605). Fed. Proc. 7, 216 (1948).
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Dubois, K.P. (1963). Toxicological Evaluation of the Anticholinesterase Agents. In: Koelle, G.B. (eds) Cholinesterases and Anticholinesterase Agents. Handbook of Experimental Pharmacology, vol 15. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-99875-1_18
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DOI: https://doi.org/10.1007/978-3-642-99875-1_18
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