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Cholinesterases and Anticholinesterase Agents

  • Book
  • © 1963

Overview

Editors:
  1. George B. Koelle

    1. Department of Pharmacology, Schools of Medicine, University of Pennsylvania, Philadelphia 4, USA

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Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 15)

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Table of contents (24 chapters)

  1. Front Matter

    Pages II-VIII
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  2. Components of Cholinergic Systems: Acetylcholine (ACh), Choline Acetylase (ChAc), and Acetylcholinesterase (AChE)

    1. Identification of Acetylcholine and Related Esters of Biological Origin

      • V. P. Whittaker
      Pages 1-39

    2. Choline Acetylase

      • David Nachmansohn
      Pages 40-54

    3. Formation, Storage, and Liberation of Acetylcholine

      • Catherine Hebb
      Pages 55-88

    4. Classification and Comparative Enzymology of the Cholinesterases and Methods for their Determination

      • Klas-Bertil Augustinsson
      Pages 89-128

    5. Ontogenesis of Cholinesterases

      • Alexander G. Karczmar
      Pages 129-186

    6. Cytological Distributions and Physiological Functions of Cholinesterases

      • George B. Koelle
      Pages 187-298

  3. Chemical Classification and Biochemical Reactions of the Anticholinesterase (Anti-ChE) Agents

    1. The Active Site of Acetylcholinesterase and Related Esterases and its Reactivity towards Substrates and Inhibitors

      • J. A. Cohen, R. A. Oosterbaan
      Pages 299-373

    2. Structure-Activity Relationships of the Reversible Anticholinesterase Agents

      • J. P. Long
      Pages 374-427

    3. Structure-Activity Relationships of the Organophosphorus Anticholinesterase Agents

      • Bo Holmstedt
      Pages 428-485

    4. Metabolism of Organophosphorus Anticholinesterase Agents

      • L. A. Mounter
      Pages 486-504

  4. Systematic Pharmacology of the Anticholinesterase (Anti-ChE) Agents

    1. Actions at Autonomic Effector Sites

      • Harry Cullumbine
      Pages 505-529

    2. Actions at Autonomic Ganglia

      • Eleanor Zaimis
      Pages 530-569

    3. Actions at the Neuromuscular Junction

      • Gerhard Werner, Albert S. Kuperman
      Pages 570-678

    4. Actions at the Central Nervous System

      • Xenia Machne, Klaus R. W. Unna
      Pages 679-700

    5. Actions on Axons, and Evidence for the Role of Acetylcholine in Axonal Conduction

      • David Nachmansohn
      Pages 701-740

    6. Actions on Insects and Other Invertebrates

      • L. E. Chadwick
      Pages 741-798

    7. Ontogenetic Effects

      • Alexander G. Karczmar
      Pages 799-832

  5. Toxicology and Therapeutic Applications of the Anticholinesterase (Anti-ChE) Agents

    1. Toxicological Evaluation of the Anticholinesterase Agents

      • Kenneth P. Dubois
      Pages 833-857

    2. Neurotoxicity of Organophosphorus Compounds

      • D. R. Davies
      Pages 858-882
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Editors and Affiliations

  • Department of Pharmacology, Schools of Medicine, University of Pennsylvania, Philadelphia 4, USA

    George B. Koelle

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