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Side Reactions in Peptide Synthesis

  • Chapter
Principles of Peptide Synthesis

Part of the book series: Reactivity and Structure Concepts in Organic Chemistry ((REACTIVITY,volume 16))

Abstract

In two reviews the author, with J. Martinez, attempted a systematic discussion of side reactions encountered in peptide synthesis. The first of these articles [1] was organized according to the amino acids which cause or suffer changes, because the individuality of amino acids leads to side reactions which are characteristic for a particular residue. Of the twenty amino acid constituents of proteins only alanine and leucine are immune from characteristic side reactions, although not from racemization. The second, more comprehensive article [2] contains also a treatment of side reactions related to methods for protection and coupling. In this volume, in which an attempt is being made to discern the principles that govern peptide synthesis, side reactions proceeding through similar mechanisms are grouped together. Racemization will be treated among other undesired reactions.

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  1. Department of Chemistry, Case Western Reserve University, Cleveland, OH, 44106, USA

    Miklos Bodanszky

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Bodanszky, M. (1984). Side Reactions in Peptide Synthesis. In: Principles of Peptide Synthesis. Reactivity and Structure Concepts in Organic Chemistry, vol 16. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-96763-4_5

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