Abstract
E. coli is the leading cause of Gram-negative bacteremia and of neonatal meningitis. In order to cause these extra-intestinally invasive infections, E. coli must traverse the gut, its normal habitat, (or from a common site of infection, the genitourinary tract), into the blood and multiply. These events require a diverse array of bacterial factors, including adhesins, iron-seeking organelles and perhaps enzymes. Extra-intestinal invasion by E. coli also requires that the organism be able to evade normal host defenses, which include serum bacteriolytic and phagocytic mechanisms. For these latter events two moieties of the bacterial outer envelope, the capsule and lipopolysaccharide (LPS) have long been considered to be important virulence factors.*
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Cross, A., Sadoff, J., Gemski, P., Kim, K.S. (1988). The Relative Role of Lipopolysaccharide and Capsule in the Virulence of E. Coli . In: Cabello, F.C., Pruzzo, C. (eds) Bacteria, Complement and the Phagocytic Cell. NATO ASI Series, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85718-8_25
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DOI: https://doi.org/10.1007/978-3-642-85718-8_25
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