Bacteria, Complement and the Phagocytic Cell

1. Front Matter

   Pages I-VIII

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2. The Murein Sacculus, the Bacterial Exoskeleton-Structure and Function in the Bacterium and Possible Role in the Host Organism

   • U. Schwarz

   Pages 1-7

3. Chemical Nature and Cellular Location of Adhesins of E. Coli

   • Klaus Jann, Heinz Hoschützky, Thomas Moch

   Pages 9-20

4. Genetics of O Antigen Polysaccharide Biosynthesis in Shigella and Vaccine Development

   • S. D. Mills, K. N. Timmis

   Pages 21-39

5. Capsular Polysaccharides (K Antigens) of Escherichia Coli

   • Klaus Jann, Barbara Jann

   Pages 41-53

6. Biogenesis of Galα(1–4)Gal binding P-pili of Uropathogenic E. Coli

   • Monica Båga, Kristina Forsman, Mikael Göransson, Frederik Lindberg, Björn Lund, Britt-Inger Marklund et al.

   Pages 55-62

7. The Evolution of M Proteins of Group A Streptococci

   • June R. Scott, Susan K. Hollingshead, Vincent A. Fischetti

   Pages 63-75

8. A New Family of Pore Forming Proteins, the Perforin Family, in Immune Cytolysis by Complement and by Lymphocytes

   • Eckhard R. Podack

   Pages 77-89

9. The Molecular Basis of the Interaction of Immunoglobulin G with Complement and Phagocytic Cells

   • D. R. Burton

   Pages 91-108

10. C3 Binding to Bacterial Surfaces

    • K. Lynn Cates, R. Paul Levine

    Pages 109-128

11. The Mode of C5b-9 Attack on Susceptible Gram Negative Bacteria

    • Peter W. Taylor

    Pages 129-138

12. Salmonella and Complement: The Critical Influence of O-Polysaccharide within LPS

    • K. Joiner, V. Jiménez-Lucho, N. Grossman, J. Foulds, M. Frank, L. Leive

    Pages 139-155

13. Ability to Activate the Alternative Complement Pathway as a Virulence Determinant in Salmonellae

    • P. Helena Mäkelä, Marianne Hovi, Harri Saxen, Matti Valtonen, Ville Valtonen

    Pages 157-176

14. Interaction of Haemophilus Influenzae with Complement

    • E. R. Moxon, J. A. Winkelstein

    Pages 177-186

15. Interaction of Pseudomonas Aeruginosa with Complement

    • Neal L. Schiller

    Pages 187-200

16. Complement-Mediated Opsonization of Group a Streptococci Inhibited by the Binding of Fibrinogen to Surface M Protein Fibrillae

    • Ellen Whitnack, Thomas P. Poirier, Edwin H. Beachey

    Pages 201-210

17. A Surface Protein of Klebsiella Pneumoniae and Escherichia Coli That Binds Phagocytes and Inhibits Phagocytosis

    • C. Pruzzo, S. Valisena, L. Baldi, G. Satta

    Pages 211-220

18. Adhesins, Serum Resistance and Cytolysins of E. Coli- Genetic Structure and Role in Pathogenicity

    • J. Hacker, W. Goebel, H. Hof, W. Konig, B. Konig, J. Scheffer et al.

    Pages 221-229

19. Phagocytosis and Intracellular Biology of Legionella Pneumophila

    • Marcus A. Horwitz

    Pages 231-237

20. Induction of Inflammation by Escherichia Coli at a Muscosal Site: Requirement for Adherence and Endotoxin

    • Catharina Svanborg Edén, Inga Engberg, Henrik Linder

    Pages 239-245

Phagocytic cells and complement are probably the most important components of host defense against bacteria which, after overcoming the mucosal and epithelial barriers, multiply in the subepithelial tissue and may threaten to disseminate and invade the blood stream and different organs. Questions concerning the factors which regulate the interactions of the bacterial cell with host defenses are a challenge to research and lead to practical applications for the prevention, treatment and diagnosis of infectious diseases. The questions of expression and regulation of virulence related bacterial genes and gene products, the specific mechanisms of defence reactions by complement and phagocytic cells, their mutual interactions with bacteria and especially bacterial surfaces are focused. Considerations on how to translate this knowledge into the management of infectious diseases are also included.

• host defenses
• infectious disease
• infectious diseases
• regulation
• virulence

• Department of Microbiology and Immunology, New York Medical College, Valhalla, USA

  Felipe C. Cabello

• Institute of Microbiology, University of Genova, Genova, Italy

  Carla Pruzzo

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