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The Mode of C5b-9 Attack on Susceptible Gram Negative Bacteria

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Bacteria, Complement and the Phagocytic Cell

Part of the book series: NATO ASI Series ((ASIH,volume 24))

Abstract

The lysis of erythrocytes by colloid osmotic deregulation upon assembly of heteropolymeric C5b-9 channels on the target membrane became the subject of intense investigation following the realization that the haemolysis assay provided a clear opportunity to unravel the complexities of the complement system (Mayer, 1984). In contrast, relatively little effort has been spent on the elucidation of the mechanism of lysis of nucleated cells and of killing of Gram-negative bacteria by complement, processes that do not follow non-cooperative or one-hit kinetics and are not due exclusively to colloid osmotic deregulation (Born and Bhakdi, 1986; Kim et al., 1987).

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Authors and Affiliations

  1. Ciba-Geigy Pharmaceuticals, Wimblehurst Road, Horsham West Sussex, RH12 4AB, UK

    Peter W. Taylor

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  1. Peter W. Taylor
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Editors and Affiliations

  1. Department of Microbiology and Immunology, New York Medical College, 10595, Valhalla, NY, USA

    Felipe C. Cabello

  2. Institute of Microbiology, University of Genova, Viale Benedetto XV 10, 16132, Genova, Italy

    Carla Pruzzo

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© 1988 Springer-Verlag Berlin Heidelberg

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Taylor, P.W. (1988). The Mode of C5b-9 Attack on Susceptible Gram Negative Bacteria. In: Cabello, F.C., Pruzzo, C. (eds) Bacteria, Complement and the Phagocytic Cell. NATO ASI Series, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-85718-8_10

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  • DOI: https://doi.org/10.1007/978-3-642-85718-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-85720-1

  • Online ISBN: 978-3-642-85718-8

  • eBook Packages: Springer Book Archive

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