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Im Gegensatz zu Nitroglyzerin führt Pentaerithrityltetranitrat zu deutlich geringerer Bildung von schädlichen Sauerstoffradikalen in Gefäßwandzellen

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Pentaerithrityltetranitrat

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Zusammenfassung

Organische Nitrate wie Nitroglyzerin oder PETN werden bei der Therapie verschiedener kardiovaskulärer Erkrankungen angewandt, bei denen verstärkte Vasodilatationen in bestimmten Kreislaufabschnitten giinstig sind, z.B. bei der Myokardischämie. Leider ist eine erfolgreiche Therapie mit Nitroglyzerin oder anderen organischen Nitraten durch das Auftreten von Nitrattoleranz eingeschränkt, die insbesondere bei der nicht intermittierenden Langzeitgabe eine ungünstige Rolle spielt. Bei der Nitrat-Toleranz handelt es sich um ein multifaktorielles Geschehen, bei dem eine mehr oder weniger stark ausgeprägte neurohumorale Gegenregulation auftritt, ferner eine verstärkte Aktion verschiedener vasokonstriktorischer Hormone beobachtet wird und schließlich auch deutlich abgeschwachte Dilatationen bei Freisetzung von EDRF bzw. Stickstoff-monoxid [1,2] hervorgerufen werden. Trotz einer Reihe von Untersuchungen sind die genauen Mechanismen, die zur Nitrat-Toleranz führen, noch nicht abgeklärt.

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Authors
  1. B. Fink
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  2. S. Dikalov
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  3. M. Schwemmer
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  4. D. Stalleicken
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  5. E. Bassenge
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Editor information

Editors and Affiliations

  1. Pharmakologisches Institut, Biozentrum Niederursel, Marie-Curie-Straße 9, 60439, Frankfurt/Main, Germany

    E. Mutschler

  2. ISIS PHARMA GmbH, Galileistraße 6, 08056, Zwickau, Germany

    A. Schütz (Apothekerin) (Apothekerin)

  3. Medizinische Fakultät, Universität Bonn, Germany

    H. T. Schneider

  4. Arbeitsgruppe Pharmakologie, Hochschule für Wirtschaft und Technik (FH) Albstadt-Sigmaringen, Medizinische Fakultät, Anton-Günther-Straße 51, 72488, Sigmaringen, Germany

    H. T. Schneider

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© 1998 Dr. Dietrich Steinkopff Verlag, Darmstadt

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Fink, B., Dikalov, S., Schwemmer, M., Stalleicken, D., Bassenge, E. (1998). Im Gegensatz zu Nitroglyzerin führt Pentaerithrityltetranitrat zu deutlich geringerer Bildung von schädlichen Sauerstoffradikalen in Gefäßwandzellen. In: Mutschler, E., Schütz, A., Schneider, H.T. (eds) Pentaerithrityltetranitrat. Steinkopff. https://doi.org/10.1007/978-3-642-85444-6_1

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  • DOI: https://doi.org/10.1007/978-3-642-85444-6_1

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-1142-2

  • Online ISBN: 978-3-642-85444-6

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