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Elementary events in excitation-contraction coupling of the mammalian myocardium

Grundprozesse der elektro-mechanischen Koppelung im Säugetiermyokard

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The Hypertrophied Heart

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Summary

Excitation-contraction coupling of the mammalian myocardium is widely assumed to comprise the following chain of events: (1) Influx of Ca++ into the cell during the plateau phase of the action potential as well as Ca++ release from the subsarcolemmal cisternae of sarcoplasmic reticulum. (2) Activation of the contractile proteins by interaction of Ca++ with the troponin-tropomyosin system. (3) Relaxation due to reuptake of Ca++ by the sarcotubular system as well as by pumping of Ca++ out of the cell through the surface membrane and the transverse tubular system. (4) Movement of Ca++ in the longitudinal tubules back to the subsarcolemmal cisternae.

A short comment is included about the effects of hypertrophy on the excitatory processes as well as on cellular structural constituents directly involved in excitation-contraction coupling.

Herrn Prof. Dr. A. Fleckenstein zum 60. Geburtstag gewidmet.

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References

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Authors and Affiliations

  1. Physiologisches Institut, Universität Freiburg, Lehrstuhl II, Hermann-Herder-Straße 7, D-7800, Freiburg i. Br, Deutschland

    Prof. Dr. med. H. Antoni

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  1. Prof. Dr. med. H. Antoni
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Editors and Affiliations

  1. Tübingen, Deutschland

    Ruthard Jacob

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© 1977 Dr. Dietrich Steinkopff Verlag, Darmstadt

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Antoni, H. (1977). Elementary events in excitation-contraction coupling of the mammalian myocardium. In: Jacob, R. (eds) The Hypertrophied Heart. Steinkopff. https://doi.org/10.1007/978-3-642-85299-2_8

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  • DOI: https://doi.org/10.1007/978-3-642-85299-2_8

  • Publisher Name: Steinkopff

  • Print ISBN: 978-3-7985-0482-0

  • Online ISBN: 978-3-642-85299-2

  • eBook Packages: Springer Book Archive

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