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Efficacy of 5-Fluorouracil by Continuous Infusion as a Radiopotentiator — Anal and Rectal Carcinoma

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Concomitant Continuous Infusion Chemotherapy and Radiation

Part of the book series: Medical Radiology ((Med Radiol Radiat Oncol))

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Abstract

The conventional treatment for both rectal and anal carcinomas remains surgery, with a characteristic 5-year survival rate of approximately 50% at each disease site (Enbald and Adami 1988). The role of radiation therapy in the management of these diseases was not recognized until fairly recently; initially radiation therapy played a palliative role but was not regarded with favor as either a definitive or an adjunct modality. Early suboptimal equipment and poor quality of delivery, coupled with disappointing results and significant morbidity, caused surgeons to remain antagonistic. Once supervoltage irradiation became available, results improved and it was possible to treat patients to tumoricidal doses within normal tissue tolerance dose levels.

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Author information

Authors and Affiliations

  1. University of Rochester School of Medicine and Dentistry, and the Daisy Marquis Jones Radiation Oncology Center, at Highland Hospital, 1000 South Avenue, Rochester, NY, 14620, USA

    Ben Sischy MD (Clinical Professor of Radiation Oncology)

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  1. Ben Sischy MD
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Editor information

Editors and Affiliations

  1. SUNY Health Science Center at Brooklyn, State University of New York, 450 Clarkson Ave., Box 1211, Brooklyn, 11203-2098, USA

    Marvin Rotman MD (Professor and Chairman, Dept. of Radiation Oncology) & C. Julian Rosenthal MD (Professor of Medicine and Oncology) (Professor and Chairman, Dept. of Radiation Oncology) &  (Professor of Medicine and Oncology)

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© 1991 Springer-Verlag Berlin Heidelberg

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Sischy, B. (1991). Efficacy of 5-Fluorouracil by Continuous Infusion as a Radiopotentiator — Anal and Rectal Carcinoma. In: Rotman, M., Rosenthal, C.J. (eds) Concomitant Continuous Infusion Chemotherapy and Radiation. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-84186-6_15

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  • DOI: https://doi.org/10.1007/978-3-642-84186-6_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-84188-0

  • Online ISBN: 978-3-642-84186-6

  • eBook Packages: Springer Book Archive

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