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Efficacy of 5-Fluorouracil by Continuous Infusion as a Radiopotentiator — Anal and Rectal Carcinoma

  • Ben Sischy
Part of the Medical Radiology book series (MEDRAD)

Abstract

The conventional treatment for both rectal and anal carcinomas remains surgery, with a characteristic 5-year survival rate of approximately 50% at each disease site (Enbald and Adami 1988). The role of radiation therapy in the management of these diseases was not recognized until fairly recently; initially radiation therapy played a palliative role but was not regarded with favor as either a definitive or an adjunct modality. Early suboptimal equipment and poor quality of delivery, coupled with disappointing results and significant morbidity, caused surgeons to remain antagonistic. Once supervoltage irradiation became available, results improved and it was possible to treat patients to tumoricidal doses within normal tissue tolerance dose levels.

Keywords

Anal Canal Rectal Carcinoma Anal Cancer Anal Carcinoma Squamous Cell Carci 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Balslev IB, Pederson M, Teglbjaerg PS et al. (1986) Postoperative radiotherapy in Dukes’ B and C carcinoma of the rectum and rectosigmoid: a randomized study. Cancer 58: 22–28PubMedCrossRefGoogle Scholar
  2. Bethune WA (1987) Carcinoma of the rectum: 508 patients with failure analysis and implication of adjuvant therapy. J Can Assoc Radiol 38: 209–216Google Scholar
  3. Butcher HR Jr (1971) Carcinoma of the rectum — a choice between an anterior resection and abdomino-perineal resection of the rectum. Cancer 28: 204–207PubMedCrossRefGoogle Scholar
  4. Byfield JE, Barone R, Medelson J et al. (1980) Infusional 5-fluorouracil and x-ray therapy for non-resectable esophageal cancer. Cancer 45: 703–708PubMedCrossRefGoogle Scholar
  5. Byfield JE, Frankel SS, Hornbeck CL et al. (1985) Phase 1 and pharmacologic study of 72-hour infused 5- fluorouracil in man. Am J Clin Oncol 8: 429–440PubMedCrossRefGoogle Scholar
  6. Courtail J, Fenadez Colmeiro JM (1960) Les indications et les résultats de la roentgentherapie et al curie dans le cancer du canal anal. Arch Mal Appar Dig Suppl 49: 43–54Google Scholar
  7. Doggett SW, Green JP, Cantril ST (1988) Efficacy of radiation therapy alone for limited squamous cell carcinoma of the anal canal. Int J Radiat Oncol Biol Phys 15: 1069–1072PubMedCrossRefGoogle Scholar
  8. Douglass HO Jr, Moertel CG (1986) Survival after postoperative combination treatment of rectal cancer. N Engl J Med 315: 1294PubMedCrossRefGoogle Scholar
  9. Enbald P, Adami HO (1988) Improved survival of patients with cancers of the colon and rectum? JNCI 80: 586–591Google Scholar
  10. Fisher B, Woolmark N, Rockette H et al. (1988) Postoperative adjuvant chemotherapy or radiation therapy for rectal cancer: results from NSABP protocol R-01. JNCI 80: 21–29PubMedGoogle Scholar
  11. Friedmann P, Garb JL, Park WC et al. (1985) Survival following moderate-dose preoperative radiation therapy of carcinoma of the rectum. Cancer 55: 967–973PubMedCrossRefGoogle Scholar
  12. Gastrointestinal Tumor Study Group (1985) Prolongation of the disease-free interval in surgically treated rectal carcinoma. N Engl J Med 312: 1465–1472CrossRefGoogle Scholar
  13. Gérard A, Buyse M, Nordlinger B et al. (1988) Preoperative radiotherapy as adjuvant treatment in rectal cancer. Final results of a randomized study of the European Organization of Research and Treatment of Cancer (EORTC). Ann Surg 208: 60–64CrossRefGoogle Scholar
  14. Gunderson LL, Sosin H (1974) Areas of failure found at reoperation (second or symptomatic look) following “curative surgery” for adenocarcinoma of the rectum. Clinicopathologic correlation and implications for adjuvant therapy. Cancer 34: 1278–1292Google Scholar
  15. Haghbin M, Sischy B, Hinson EJ (1988) Combined modality preoperative therapy in poor prognostic rectal adenocarcinoma. Radiother Oncol 13: 75–81PubMedCrossRefGoogle Scholar
  16. Heidelberger C, Griesbach L, Montago BJ et al. (1958) Studies on fluorinated pyrimidines. 11. Effects on transplanted tumors. Cancer Res 18: 305–317PubMedGoogle Scholar
  17. Learning RH, Stearns MW Jr, Deddish MR (1961) Preoperative irradiation in rectal carcinoma. Radiology 77: 257–263Google Scholar
  18. Lokich JJ (1985) Optimal schedule for 5-fluorouracil chemotherapy. Intermittent bolus of continuous infusion? Am J Clin Oncol 8: 445–448PubMedCrossRefGoogle Scholar
  19. Looney WB, Hopkins HA, MacLeod MS et al. (1979) Solid tumor models for the assessment of different treatment modalities. XII. Combined chemotherapy-radiotherapy: variation of time interval between time of administration of 5-fluorouracil and radiation and its effect on the control of tumor growth. Cancer 44: 437–445PubMedCrossRefGoogle Scholar
  20. Myers CE, Diasio R, Elliot HM et al. (1976) Pharmacokinetics of the fluoropyrimidines: implication for their use. Cancer Treat Rev 3: 175–183PubMedCrossRefGoogle Scholar
  21. Nakajima Y, Miyamoto T, Tanake M et al. (1979) En-hancement of mammalian cell killing by 5-fluorouracil in combination with x-rays. Cancer Res 39: 3736–3637Google Scholar
  22. Nigro N, Vaitkevicius VK, Considine B Jr (1974) Combined therapy for cancer of the anal canal: a preliminary report. Dis Colon Rectum 17: 354–356PubMedCrossRefGoogle Scholar
  23. Páhman L, Glimelius B, Graffman S (1986) Pre- versus postoperative radiotherapy in rectal carcinoma: an interim report from a randomized multicentre trial. Br J Surg 72: 961–966CrossRefGoogle Scholar
  24. Peters RK, Mack TM, Berstein L (1984) Parallels in the epidemiology of selected anogenital carcinomas. JNCI 72: 609–615PubMedGoogle Scholar
  25. Rao AR, Dagan AR, Chan PM et al. (1981) Patterns of recurrence following curative resection alone for adenocarcinoma of the rectum and sigmoid colon. Cancer 48: 1492–1495PubMedCrossRefGoogle Scholar
  26. Rockwell S (1982) Cytotoxicities of mitomycin C and x-rays to íerobic and hypoxic cells in vitro. Int J Radiat Oncol B 3l Phys 8: 1035–1039CrossRefGoogle Scholar
  27. Roswit B, Higgins CA, Park WC et al. (1975) Preoperative radiation for carcinoma of the rectum and rectosigmoid. Cancer 35: 1597–1602PubMedCrossRefGoogle Scholar
  28. Roux-Berger JL, Ennuyer A (1948) Carcinoma of the anal canal; Statistic Foundation Curie. AJR 60: 807–815Google Scholar
  29. Sischy B (1985) The use of radiation therapy combined with chemotherapy in the management of squamous cell carcinoma of the anus and marginally resectable adenocarcinoma of the rectum. Int J Radiat Oncol Biol Phys 11: 1587–1593CrossRefGoogle Scholar
  30. Sishcy B, Remington JH, Sobel SH et al. (1980) Treatment of carcinoma of the rectum and squamous cell carcinoma of the anus by combination chemotherapy, radiotherapy and operation. Surg Gynecol Obstet 151: 369–371Google Scholar
  31. Sischy B, Doggett RLS, Krall JM et al. (1989) JNCI 81: 850–856PubMedGoogle Scholar
  32. Slater G, Greenstein A, Aufses AH Jr (1984) Anal carcinoma in patients with Crohn’s disease. Ann Surg 199: 348–350PubMedCrossRefGoogle Scholar
  33. Spremullt EN, Leith JT, Bliven SF et al. (1983) Response of a human colon adenocarcinoma (DLD-I) to x- irradiation and mitomycin C in vitro. Int J Radiat Oncol Biol Phys 9: 1209–1212CrossRefGoogle Scholar
  34. Sweet RH (1947) Results of treatment of epidermoid carcinoma of the anus and rectum. Surg Gynecol Obstet 84: 967–972PubMedGoogle Scholar
  35. Vietti T, Enggerding R, Valeriote F (1971) Combined effect of x-radiation and 5-fluorouracil on survival of transplanted leukemic cells. JNCI 47: 865–870PubMedGoogle Scholar
  36. Vigilotti A, Rich TA, Romsdahl MM et al. (1987) Postoperative adjuvant radiotherapy for adenocarcinoma of the rectum and recto-sigmoid. Int J Radiat Oncol Biol Phys 13: 999–1006CrossRefGoogle Scholar
  37. Vogelzang NJ (1984) Continuous infusion chemotherapy: a critical review. J Clin Oncol 2: 1289–1304PubMedGoogle Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • Ben Sischy
    • 1
  1. 1.University of Rochester School of Medicine and Dentistry, and the Daisy Marquis Jones Radiation Oncology Center, at Highland HospitalRochesterUSA

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