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Concomitant Continuous Infusion Chemotherapy and Radiation

  • Textbook
  • © 1991

Overview

Editors:
  1. Marvin Rotman

    1. SUNY Health Science Center at Brooklyn, State University of New York, Brooklyn, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. C. Julian Rosenthal

    1. SUNY Health Science Center at Brooklyn, State University of New York, Brooklyn, USA

    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Medical Radiology (MEDRAD)

Part of the book sub series: Radiation Oncology (Med Radiol Radiat Oncol)

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Table of contents (35 chapters)

  1. Front Matter

    Pages I-XIV
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  2. The Development of Chemotherapy Drugs as Radiosensitizers: an Overview

    1. The Development of Chemotherapy Drugs as Radiosensitizers: an Overview

      • C. Julian Rosenthal, Marvin Rotman
      Pages 1-9

  3. Principles of Infusion Chemotherapy

    1. Front Matter

      Pages 11-11
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    2. Experimental Rationale for Continuous Infusion Chemotherapy

      • R. Brian Mitchell, Mark J. Ratain, Nicolas J. Vogelzang
      Pages 13-27

    3. Combination Chemotherapy by Infusion in Hematological Malignancies

      • Leonard Saltz, Morton Coleman, Peter Yi
      Pages 29-34

    4. Combination Chemotherapy by Infusion in Solid Tumors

      • James D. Ahlgren
      Pages 35-47

    5. Admixtures of Chemotherapy Agents by Continuous Infusion

      • Jacob J. Lokich
      Pages 49-55

    6. Time-Specified Delivery of Chemotherapy by Implantable Programmable Pumps — Preliminary Data on 5-Fluoro-2’-deoxyuridine

      • Reinhard von Roemeling, Rosellen Lanning, Henry Wagner Jr., Ronald DeConti, Lawrence E. Scheving, William Hrushesky
      Pages 57-65

    7. Advances in the Technology of Continuous Infusion

      • Jose R. Marti
      Pages 67-73

  4. Radiosensitization and Radioprotection

    1. Front Matter

      Pages 75-75
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    2. Hypoxic Cell Sensitizers

      • C. Norman Coleman
      Pages 77-84

    3. Glutathione, a Determinant of Response to Cancer Treatment

      • Dwight Kaufman, James B. Mitchell, Angelo Russo
      Pages 85-89

    4. Radiosensitization of Nonhypoxic Cells by Halogenated Pyrimidines

      • Timothy J. Kinsella
      Pages 91-96

    5. Perfluorocarbon Emulsion and Oxygen with Concomitant Radiation Therapy in Primary High Grade Brain Tumors

      • Richard G. Evans, Bruce F. Kimler, Robert A. Morantz, Tribhawan S. Vats, Vici Liston, Norma L. Lowe
      Pages 97-100

    6. Chemo- and Radioprotection: Clinical Trials Combining WR-2721 with Cisplatin and Cyclophosphamide

      • Donna Glover, Clare Weiler, Stephen Grabelsky
      Pages 101-104

    7. Biological Modifiers’ Potential for Radioprotection

      • Gary B. Thurman, Robert K. Oldham
      Pages 105-111

  5. 5-Fluorouracil Radiopotentiation and Its Modulation by Other Agents

    1. Front Matter

      Pages 113-113
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    2. Theoretical Basis and Clinical Applications of 5-Fluorouracil as a Radiosensitizer — an Overview

      • John E. Byfield
      Pages 115-127

    3. Efficacy of 5-Fluorouracil by Continuous Infusion as a Radiopotentiator — Anal and Rectal Carcinoma

      • Ben Sischy
      Pages 129-135

    4. Hepatic Metastases from Gastrointestinal Malignancies and Hepatocellular Carcinoma

      • Marvin Rotman, Hassan Aziz, Seth Reiner, C. Julian Rosenthal, Jean-Philippe Austin, Richard S. Stark
      Pages 137-142
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Keywords

About this book

The administration of chemotherapeutic agents by continuous infusion with concomitant radiation therapy heralds a new approach in the treatment of cancer. This comprehensive book on the subject includes, besides a discussion of its scientific basis, the most promising clinical data on the use of continuous infusion chemotherapy and radiation. Thus, it is an important update for clinical investigators involved in frontline research as well as for practicing physicians participating in the direct care of cancer patients. The contributions include the latest results of this new approach in a number of tumor sites. There is a detailed description of the principles of radiosensitization for malignant tumors and radioprotection for normal tissues; these are the principles which have led to concrete clinical applications. There is also a presentation of the most recent data on the beneficial effects resulting from the administration of commonly used drugs, such as 5-fluorouracil, cisplatinum and adriamycin, with concomitant radiation therapy. Much of the data has never before been published. The wealth of information in this volume makes it a valuable reference; at the same time it gives practicing physicians a detailed presentation of various therapeutic regimens which they could administer in their daily clinical practice. In the future, this innovative cancer treatment may lead to the decreased need for radical surgery and the increased ability to preserve organ function.

Editors and Affiliations

  • SUNY Health Science Center at Brooklyn, State University of New York, Brooklyn, USA

    Marvin Rotman, C. Julian Rosenthal

Bibliographic Information

  • Book Title: Concomitant Continuous Infusion Chemotherapy and Radiation

  • Editors: Marvin Rotman, C. Julian Rosenthal

  • Series Title: Medical Radiology

  • DOI: https://doi.org/10.1007/978-3-642-84186-6

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1991

  • Softcover ISBN: 978-3-642-84188-0Published: 19 January 2012

  • eBook ISBN: 978-3-642-84186-6Published: 06 December 2012

  • Series ISSN: 0942-5373

  • Series E-ISSN: 2197-4187

  • Edition Number: 1

  • Number of Pages: XIV, 304

  • Number of Illustrations: 9 b/w illustrations

  • Topics: Oncology, Imaging / Radiology

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

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