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Interactions of Hyperthermia with Hypoxic Cell Sensitisers

  • Conference paper
Preclinical Hyperthermia

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 109))

Abstract

The role of hypoxic cell radiosensitisers has been extensively investigated for the past two decades. Efficacy in experimental models awaits validation in the clinic, but newer drugs currently entering clinical trial show considerable promise. Preferential hypoxic cell cytotoxicity by these electron-affinic agents was demonstrated about 10 years ago. Soon after the enhancement of this cytotoxity by hyperthermia was reported in cells in monolayer culture (Stratford and Adams 1977; Hall et al. 1977), multicellular tumour spheroids (Morgan and Bleehen 1981) and experimental tumours in vivo (Bleehen et al. 1977a; George et al. 1977). The purpose of this paper is briefly to review the topic of the interaction of heat with some hypoxic cell sensitisers. In addition we will also present some of our recent data on aspects of the pharmacology of this combination of treatment modalities. This updates reviews presented at the 2nd International Hyperthermia Symposium in Essen (Bleehen et al. 1978) and more recently by Adams et al. (1982).

We wish to thank our many colleagues who have contributed to this work, especially Ms. D.J.Honess. Part of this work was supported by a grant from the Cancer Research Campaign.

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Authors and Affiliations

  1. University Department of Clinical Oncology and Radiotherapeutics, The Medical School, Hills Road, Cambridge, CB2 2QH, Great Britain

    N. M. Bleehen, M. I. Walton & P. Workman

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  1. N. M. Bleehen
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  2. M. I. Walton
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  3. P. Workman
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Editors and Affiliations

  1. Abteilung Strahlentherapie (Med. Klinik) Radiologische Klinik, Albert-Ludwigs-Universität, Hugstetter Straße 55, 7800, Freiburg, Germany

    Wolfgang Hinkelbein , Gregor Bruggmoser , Rupert Engelhardt  & Michael Wannenmacher , ,  & 

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© 1988 Springer-Verlag Berlin Heidelberg

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Bleehen, N.M., Walton, M.I., Workman, P. (1988). Interactions of Hyperthermia with Hypoxic Cell Sensitisers. In: Hinkelbein, W., Bruggmoser, G., Engelhardt, R., Wannenmacher, M. (eds) Preclinical Hyperthermia. Recent Results in Cancer Research, vol 109. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-83263-5_16

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  • DOI: https://doi.org/10.1007/978-3-642-83263-5_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-83265-9

  • Online ISBN: 978-3-642-83263-5

  • eBook Packages: Springer Book Archive

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