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Mutagens as Teratogens: A Correlative Approach

  • Chapter
Teratogenesis and Reproductive Toxicology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 65))

Abstract

The recent development and application of short-term tests for the detection of mutagenic activity has generated several efforts to determine th extent of the interrelationship of genotoxicity with other pathologic end points. The most enthusiastic of these efforts has been directed toward the correlation of mutagenic and carcinogenic activities (McCann et al. 1975). Several major studies have shown that this correlation is in the range of about 67% (Kawachi et al. 1980) to about 90% (McCann et al. 1975). This correlation has permitted the use of short-term assay results to predict the probability of carcinogenic hazard or safety of a variety of test substances. Other pathologic end points, such as teratology, have not given such clear-cut correlation with genetic toxicity (Kalter 1971). The most significant correlation should include a representative sampling from most classes of existing compounds, weighted according to the importance of that class in exposure to the population. However, the scientific impetus to evaluate all aspects of toxicity for chemicals with known biologic activity has resulted in a disproportionate number of cancer chemotherapeutic agents and alkylating agents among those compounds tested to date for teratology and genetic toxicology. Although this condition may have a marked influence on the degree of correlation, the comparative process must begin.

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Authors
  1. C. A. Schreiner
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  2. H. E. Holden Jr.
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Editor information

Editors and Affiliations

  1. Jefferson Medical College, 1020 Locust Street, Philadelphia, PA, 19107, USA

    E. Marshall Johnson Ph.D. (Professor and Chairman of Department of Anatomy, Director of Daniel Baugh Institute) (Professor and Chairman of Department of Anatomy, Director of Daniel Baugh Institute)

  2. Department of Anatomy, Daniel Baugh Institute, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA, 19107, USA

    Devendra M. Kochhar Ph.D.

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© 1983 Springer-Verlag Berlin Heidelberg

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Schreiner, C.A., Holden, H.E. (1983). Mutagens as Teratogens: A Correlative Approach. In: Johnson, E.M., Kochhar, D.M. (eds) Teratogenesis and Reproductive Toxicology. Handbook of Experimental Pharmacology, vol 65. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81919-3_9

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  • DOI: https://doi.org/10.1007/978-3-642-81919-3_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-81921-6

  • Online ISBN: 978-3-642-81919-3

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