Teratogenesis and Reproductive Toxicology

  • E. Marshall Johnson
  • Devendra M. Kochhar

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 65)

Table of contents

  1. Front Matter
    Pages I-XVI
  2. Epidemiology and Bioavailability

    1. Front Matter
      Pages 1-1
    2. B. A. Schwetz, K. S. Rao, L. W. Rampy
      Pages 3-6
    3. S. T. Chao, M. R. Juchau
      Pages 31-48
  3. Mechanisms of Teratogenesis

    1. Front Matter
      Pages 63-63
    2. J. L. Sever
      Pages 65-73
    3. K. P. Chepenik, S. A. Waldman
      Pages 93-111
    4. D. S. Salomon
      Pages 113-134
    5. C. A. Schreiner, H. E. Holden Jr.
      Pages 135-168
  4. Adverse Effects on Function

  5. In Vitro Screens of Teratogenic Potential

    1. Front Matter
      Pages 287-287
    2. J. H. Greenberg
      Pages 289-299
    3. D. M. Kochhar
      Pages 301-314

About this book

Introduction

The resolution of links between exposure to components of our complex environmental and causation of reproductive effects in the population constitutes an important problem in the field of toxicology. The focus of this volume is developmental toxicology, which represents one aspect of reproductive toxicology dealing with the study of adverse effects on the developing conceptus. Developmental toxicology, which includes teratogenesis as one of its manifesta­ tions, provides a fertile field for research in several basic and clinical disciplines; this field also receives input from several disoiplines such as developmental and molecu­ lar biology, pathology, pharmacology and toxicology, pediatrics and neonatology, and epidemiology. More recently we h~ve seen an emergence of interest in other fields such as perinatal physiology and postnatal behavior which have now become incorporated into the mainstream of research in this discipline. The present volume is an effort to provide a sampling of concepts currently under active investigation in several of the above fields. The authors have endeavored to provide up-to-date in­ formation on the following topics: detection and analysis of potential hazards to the conceptus in the workplace, pharmacokinetic aspects of the maternal/placental! fetal complex and its relationship to human birth defects, and probable mechanisms of teratogenesis as uncovered in certain well-defined situations. Also included are summaries of newer investigations on the emerging field of postnatal functional evaluations, i. e. , adverse effects on adult activities resultant from in utero exposure to toxic substances.

Keywords

Pharmakologie biology environment pharmacology physiology research toxicology

Editors and affiliations

  • E. Marshall Johnson
    • 1
  • Devendra M. Kochhar
    • 2
  1. 1.Jefferson Medical CollegePhiladelphiaUSA
  2. 2.Department of Anatomy, Daniel Baugh InstituteThomas Jefferson UniversityPhiladelphiaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-81919-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1983
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-81921-6
  • Online ISBN 978-3-642-81919-3
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • About this book
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