Abstract
Mammalian susceptibility to teratogenic insult has been of interest and concern for several years. It was apparent as early as the 1940 s that the developing embryo was both exposed to and at risk of injury by exogenous agents or conditions (Warkany 1971). Until recently, expression of developmental abnormalities was thought to be limited to gross structural malformations, and the type of malformations observed were thought to be interrelated with the exact gestational or developmental stage at the time of exposure, as well as with the actual target phase or cell line. Additional evidence suggests, in the case of central nervous system (CNS) and lung evaluation, that the structural level and degree of damage may also dictate the form of expression (Hutchings and Gaston 1974; Vorhees et al. 1978; Rodier 1977; Jensh et al. 1978; Newman and Johnson 1980; Christian and Johnson to be published). A subtle alteration, cellular or biochemical, may not cause a gross structural malformation, yet markedly affect the ability or efficiency by which a particular cell line or organ functions. Two questions arise. First, should a prenatally acquired functional deficit be classified as a teratologic effect; and second, what is the importance of this type of expression? It is our feeling that when a prenatal insult is expressed as a functional deficit with an impact that either threatens the life of an infant or affects the quality of life, it is indeed a teratologic incidence and is as important as any gross structural malformation. Therefore, the primary question becomes “what actual change has occurred and how may that change be manifested?” With this in mind, we have explored the sensitivity of the developing lung.
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References
Adams FH, Fujiwara T, Rowshan L (1963 a) The nature and origin of the fluid in the fetal lamb lung. J Pediatr 63:881–888
Adams FH, Moss AJ, Fagen L (1963 b) The tracheal fluid in the fetal lamb. Biol Neonate 5:151–158
Alescio T (1973) Effect of a proline analogue acetidine-2-carboxylic acid on the morphogenesis in vitro of mouse embryonic lung. J Embryol Exp Morphol 29:439–451
Alescio T, Cassini A (1962) Induction in vitro of tracheal buds by pulmonary mesenchyme grafted on tracheal epithelium. J Exp Zool 150:83–94
Alescio T, di Michele M (1968) Relationship of epithelial growth to mitotic rate in mouse embryonic lung developing in vitro. J Embryol Exp Morphol 19:227–237
Armenti VT, Johnson EM (1978) Effects of retinyl acetate on fetal lung maturation in the rat [Abstr]. Teratology 17:46A
Armenti VT, Johnson EM (1979) Effects of maternal hypervitaminosis A on perinatal rat lung histology. Biol Neonate 36:305–310
Avery ME, Mead J (1959) Surface properties in relation to atelectasis and hyaline membrane disease. Am J Dis Child 97:517–523
Balis JU, Delivori M, Conen PE (1966) Maturation of postnatal human lung and idiopathetic respiratory distress syndrome. Lab Invest 15:530–546
Barrett CT, Sevanian A, Lavin N, Kaplan SA (1976) Role of adenosine 3′,5′ Monophosphate in maturation of fetal lungs. Pediatr Res 10:621–625
Biezenski JJ (1976) Pulmonary surfactant amniotic fluid lipids. Obstet Gynecol Annu 5:71–102
Blackburn WR, Travers H, Potter DM (1972) The role of pituitary-adrenalthyroid axes m lung differentiation I. Studies of the cytology and physical properties of anencephalic fetal rat lung. Lab Invest 26:306–318
Boyden EA (1974) The mode of origin of pulmonary acini and respiratory bronchioles in the fetal lung. Am J Anat 141:317–328
Boyden EA (1976) The development of the lung in the pig-tail monkey (Macaca nemestrina ,L). Anat Rec 186:15–38
Brumley GW, Chernick V, Hodson WA, Normand C, Fenner A, Avery ME (1967) Correlations of mechanical stability, morphology, pulmonary surfactant, and phospholipid content in developing lamb lung. J Clin Invest 46:863–873
Burri PH, Dbaly J, Weibel ER (1974) The postnatal growth of the rat lung I. Morphometry. AnatRec 178:711–730
Carmel JA, Friedman F, Adams FH (1965) Fetal tracheal ligation and lung development. Am J Dis Child 109:452–456
Christian MS, Johnson EM (to be published) Postnatal functional teratology resulting from fetal insult I. Alteration of gastrointestinal physiology. J Environ Pathol Toxicol
Clements JA, Platzker ACG, Tierney DF et al. (1972) Assessment of the risk of the respiratory-distress syndrome by a rapid test for surfactant in amniotic fluid. N Engl J Med 286:1077–1081
Conney AH (1967) Pharmacological implications of microsomal enzyme induction. Pharmacol Rev 19:317–366
Daston GP (1981 a) Effects of cadmium on the prenatal ultrastructural maturation of rat alveolar epithelium. Teratology 23:75–84
Daston GP (1981 b) Effects of maternal cacjmium exposure on fetal lung maturation: relation to fetal zinc levels [Abstr]. Teratology 23:32A
Daston GP, Grabowski CT (1979) Toxic effects of cadmium on the developing rat lung I. Altered pulmonary surfactant and the’induction of respiratory distress syndrome. J Toxicol Environ Health 5:973–983
Davies G, Reid L (1970) Growth of the alveoli and pulmonary arteries in childhood. Thorax 25:669–681
Draisey TF, Gagneja GL, Thibert RJ (1977) Pulmonary surfactant and amniotic fluid insulin. Obstet Gynecol 50:197–199
Dunnill MS (1962) Postnatal growth of the lung. Thorax 17:329–333
Enhörning G, Grossman G, Robertson B (1973) Tracheal deposition of surfactant before the first breath. Am Rev Respir Dis 107:921–927
Fariday EE (1975) Effect of maternal malnutrition on surface activity of fetal lungs in rats. J Appl Physiol 39:535–540
Farrell PM (1973) Regulation of pulmonary lecithin synthesis. In: Villee CA; ViUie DB, Zuckerman J (eds) Respiratory distress syndrome. Academic Press, New York, pp 271– 293
Fine R, McCullough B, Collins JF, Johanson WG Jr (1979) Lung elasticity in regional and diffuse pulmonary fibrosis. J Appl Physiol 47:138–144
Gil J, Reiss OK (1973) Isolation and characterization of lamellar bodies and tubular myelin from rat lung homogenates. J Cell Biol 58:152–171
Glass L, Rajegowda BK, Evans HE (1971) Absence of respiratory distress syndrome in premature infants of heroin-addicted mothers. Lancet 2:685–686
Gluck L, Kulovich MV, Burer RC Jr, Brenner PH, Anderson GG, Spellacy WN (1971) Diagnosis of the respiratory distress syndrome by amniocentesis. Am J Obstet Gynecol 109:440–445
Gluck L, Kulovich MV, Eidelman AI, Cordero L, Khazin AF (1972) Biochemical development of surface activity in mammalian lung IV. Pulmonary lecithin synthesis in the human fetus and newborn and etiology of the respiratory distress syndrome. Pediatr Res 6:81–99
Haas-Denk S, Krieglsteiner P, Wreidt-Lübbe I, Erhardt W, Münnich W, Blümel G (1976) Tissue-plasminogen-activators of maternal and fetal rat lungs after application of betamethasone or bromhexine-metabolite VIII. Z Geburtshilfe Perinatol 180:398–403
Hamosh M, Hamosh P (1977) The effect of prolactin on the lecithin content of fetal rabbit lung. J Clin Invest 59:1002–1005
Hutchings DE, Gaston J (1974) The effects of vitamin A excess administered during the mid-fetal period on learning and development in rat offspring. Dev Psychobiol 7:225–233
Jensh RP, Ludlow J, Weinberg I, Vogel WH, Rudder T, Brent RL (1978) Studies concerning the postnatal effects of protracted low dose prenatal 915 MHz microwave radiation [Abstr]. Teratology 17:21A
Johnson EM, Nelson MM, Monie IW (1963) Effects of transitory pteroylglutamic acid (PGA) deficiency on embryonic and placental development in the rat. Anat Rec 146:215–224
Karotkin EH, Kido M, Cashore WJ et al. (1976 a) Acceleration of fetal lung maturation by aminophyllin in pregnant rabbits. Pediatr Res 10:722–724
Karotkin EH, Kido M, Redding RA et al. (1976 b) The inhibition of pulmonary maturation in the fetal rabbit by maternal treatment with phenobarbital. Am J Obstet Gynecol 124:529–531
Kauffman SL (1977) Acceleration of canalicular development in lungs of fetal mice exposed transplacentally to dexamethasone. Lab Invest 36:395–401
Kauffman SL, Burri PH, Weibel ER (1974) The postnatal growth of the rat lung II. Autora-diograph. Anat Rec 180:63–76
Klaus MH, Clements JA, Havel RJ (1961) Composition of surface-active material isolated from beef lungs. Proc Natl Acad Sci USA 47:1858–1859
Liggins GC (1968) Premature parturition after infusion of corticotropin or Cortisol into fetal lambs. J Endocrinol 42:323–329
Liggins GC, Kennedy PC, Holm LW (1967) Failure of initiation of parturition after electrocoagulation of the pituitary of the fetal lamb. Am J Obstet Gynecol 98:1080–1086
Lipshaw LA, Weinberg JH, Sherman AI, Foa F, Foa P (1973) A rapid method for measuring the lecithin-sphingomyelin ratio in the amniotic fluid. Obstet Gynecol 42:93–98
Mason RJ, Dobbs LG, Greenleaf RD, Williams MC (1977) Alveolar type II cells. Fed Proc 36:2697–2702
Matthews LM, Johnson EM, Newman LM (1981) Introduction of late gestational terato-genesis in rat lung by hypervitaminosis A. Teratology 23:253–258
Morawetz F (1970) Zur Entwicklung der menschlichen Lunge. Pneumonologie 143:136–138
Newman LM, Johnson EM (1980) Characterization of morphological and physiological abnormalities following fetal hypervitaminosis A exposure in the rat [Abstr]. Teratology 21:58A
Newman LM, Johnson EM (1981) Effect of fetal exposure to hypervitaminosis A on lung compliance in the neonatal rat [Abstr]. Teratology 23:54A
Newman LM, Johnson EM, Armenti VT (1978) Effect of prenatal vitamin A on neonatal respiratory frequency and O2 consumption in the long-Evans’ rat [Abstr]. Teratology 17:44A
O’Hare KH, Sheridan MN (1970) Electron microscopic observations on the morphogenesis of the albino rat lung, with special reference to pulmonary epithelial cells. Am J Anat 127:181–206
Rodier PM (1977) Correlations between postnatally-induced alterations in CNS cell population and postnatal functions. Teratology 16:235–246
Roloff DW, Howatt WF, Kanto WP, Borer RC (1975) Morphine administration to pregnant rabbits: effect on fetal growth and lung development. Addict Dis 2:369–379
Rooney SA, Nardone LL, Shapiro DL, Motoyama EK, Gobran L, Zachringer N (1977) The phospholipids of rabbit type II alveolar epithelial cells: comparison with lung lavage, lung tissue, alveolar macrophages and a human alveolar tumor cell line. Lipids 12:438–442
Rudnick D (1933) Developmental capacities of the chick lung in chorioallantoic grafts. J Exp Zool 66:135–154
Scarpelli EM (1975) Perinatal respiration. In: Scarpelli EM (ed) Pulmonary physiology of the fetus, newborn, and child. Lea & Febiger, Philadelphia, pp 117–139
Stanley NN, Alper R, Cunningham EL, Cherniack NS, Kafalider NA (1975) Effects of a molecular change in collagen on lung structure and mechanical function. J Clin Invest 55:1195–1201
Strang LB (1977) Growth and development of the lung: fetal and postnatal. Annu Rev Physiol 39:253–276
Taderera JV (1967) Control of lung differentiation in vitro. Dev Biol 16:489–512
Thurlbeck WM (1975) Postnatal growth and development of the lung. Am Rev Respir Dis 111:803–844
Torday JS, Zinman HM, Nielsen HC (1981) Reciprocal relationship between fetal lung cell proliferation and functional differentiation in vivo, 6/I [Abstr]. Fed Proc 40:557
Vaccaro C, Brody JS (1978) Ultrastructure of developing alveoli I. The role of the interstitial fibroblast. Anat Rec 192:467–480
Van Petten GR, Bridges R (1979) The effects of prolactin on pulmonary maturation in the fetal rabbit. Am J Obstet Gynecol 134:711–714
Vojnik C, Hurley LS (1977) Abnormal prenatal lung development resulting from maternal zinc deficiency in rats. J Nutr 107:862–872
Vorhees CV, Brunner RL, McDaniel CR, Butcher RE (1978) The relationship of gestational age to vitamin A induced postnatal dysfunction. Teratology 17:271–276
Warkany J (1971) Congenital malformations. Year Book, Chicago
Weibel ER, Kistler GS, Tondury G (1966) A stereologic electron microscope study of “tubular myelin figures” in alveolar fluids of rat lungs. Z Zeilforsch Mikrosk Anat 69:418–427
Wessels NK (1970) Mammalian lung development. Interactions in formation and morphogenesis of tracheal buds. J Exp Zool 175:455–466
Williams MC (1977) Conversion of lamellar body membranes into tubular myelin in alveoli of fetal rat lungs. J Cell Biol 72:260–277
Williams MC, Mason RJ (1977) Development of the type II cell in the fetal rat lung. Am Rev Respir Dis 115:37–47
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Newman, L.M., Johnson, E.M. (1983). Abnormal Lung Function Induced by Prenatal Insult. In: Johnson, E.M., Kochhar, D.M. (eds) Teratogenesis and Reproductive Toxicology. Handbook of Experimental Pharmacology, vol 65. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81919-3_12
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DOI: https://doi.org/10.1007/978-3-642-81919-3_12
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