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Behavioral Testing Procedures: A Review

  • Chapter
Teratogenesis and Reproductive Toxicology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 65))

Abstract

Behavioral teratology, a multidisciplinary science which is less than two decades old, is concerned with the identification of agents which cause abnormal behavior in offspring, and the assessment of functional consequences of an insult during prenatal development. This area of investigation also includes subtle biochemical and anatomic disturbances which produce functional abnormalities. One of the basic premises of behavioral teratology is that functional alterations, usually deficits, may be present even when no morphological abnormalities are observed (Barlow and Sullivan 1975; Rodier 1978). Behavioral teratology has been defined by Werboff and Gottlief (1963) as the study of “deleterious changes in the behavior of animals, attributed to teratogenic agents administered during prenatal development.” This definition is too limited, however, since an agent must be predetermined to be a teratogen according to classical morphological standards (Jensh 1980; Werboff and Gottlieb 1963).

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  1. R. P. Jensh
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Editors and Affiliations

  1. Jefferson Medical College, 1020 Locust Street, Philadelphia, PA, 19107, USA

    E. Marshall Johnson Ph.D. (Professor and Chairman of Department of Anatomy, Director of Daniel Baugh Institute) (Professor and Chairman of Department of Anatomy, Director of Daniel Baugh Institute)

  2. Department of Anatomy, Daniel Baugh Institute, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA, 19107, USA

    Devendra M. Kochhar Ph.D.

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Jensh, R.P. (1983). Behavioral Testing Procedures: A Review. In: Johnson, E.M., Kochhar, D.M. (eds) Teratogenesis and Reproductive Toxicology. Handbook of Experimental Pharmacology, vol 65. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-81919-3_10

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  • DOI: https://doi.org/10.1007/978-3-642-81919-3_10

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