The Tfm Mutation Affects the Nuclear-Cytosol Androgen-Receptor Protein

  • Susumu Ohno
Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 11)


All the pertinent observations made on the androgen responsiveness of Tfm/Y mice and rats were summarized in Chap. 12. As a result, the X-linked Tfm locus emgerged as the master regulatory gene of the secondary (extragonadal) sex-determining meachanism. It can be recalled that in the primary (gonadal) sex-determining meacanism, it was the master regulatory gene product, H-Y antigen, which was unequivocally identified. What remains to be worked out is the genetics of H-Y antigen expression, in which not only the Y but also the X and possibly also an autosome are involved.


Androgen Receptor Mouse Kidney Wolffian Duct Target Cell Type Epithelial Response 
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Copyright information

© Springer-Verlag Berlin · Heidelberg 1979

Authors and Affiliations

  • Susumu Ohno
    • 1
  1. 1.Department of Biology, City of HopeNational Medical CenterUSA

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