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The Tfm Mutation Affects the Nuclear-Cytosol Androgen-Receptor Protein

  • Susumu Ohno
Part of the Monographs on Endocrinology book series (ENDOCRINOLOGY, volume 11)

Abstract

All the pertinent observations made on the androgen responsiveness of Tfm/Y mice and rats were summarized in Chap. 12. As a result, the X-linked Tfm locus emgerged as the master regulatory gene of the secondary (extragonadal) sex-determining meachanism. It can be recalled that in the primary (gonadal) sex-determining meacanism, it was the master regulatory gene product, H-Y antigen, which was unequivocally identified. What remains to be worked out is the genetics of H-Y antigen expression, in which not only the Y but also the X and possibly also an autosome are involved.

Keywords

Androgen Receptor Mouse Kidney Wolffian Duct Target Cell Type Epithelial Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1979

Authors and Affiliations

  • Susumu Ohno
    • 1
  1. 1.Department of Biology, City of HopeNational Medical CenterUSA

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