Skip to main content
SpringerLink
Log in

Major Sex-Determining Genes

  • Book
  • © 1979

Overview

Authors:
  1. Susumu Ohno

    1. Department of Biology, City of Hope, National Medical Center, USA

    View author publications

    You can also search for this author in PubMed   Google Scholar

Part of the book series: Monographs on Endocrinology (ENDOCRINOLOGY, volume 11)

This is a preview of subscription content, log in via an institution to check access.

Access this book

Log in via an institution
eBook USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Other ways to access

Licence this eBook for your library

Institutional subscriptions

Table of contents (13 chapters)

  1. Front Matter

    Pages I-XIII
    Download chapter PDF

  2. Sexual Dimorphism as a Dispensable Appendage of the Sex-Determining Mechanism

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. Why Sexual Dimorphism?

      • Susumu Ohno
      Pages 3-6

    3. Man as a Sexually Dimorphic Species

      • Susumu Ohno
      Pages 7-10

    4. Male Chauvinism and a Misunderstanding of Sexual Dimorphism

      • Susumu Ohno
      Pages 11-13

  3. H-Y Antigen and Chromosomal Determination of Primary (Gonadal) Sex

    1. Front Matter

      Pages 15-15
      Download chapter PDF

    2. The Number of Genes in the Mammalian Genome and the Need for Master Regulatory Genes

      • Susumu Ohno
      Pages 17-21

    3. The Mammalian Sex Chromosomes

      • Susumu Ohno
      Pages 22-28

    4. Initial Gonadal Differentiation and the History of H-Y Antigen

      • Susumu Ohno
      Pages 29-38

    5. Testis-Organizing Function of H-Y Antigen

      • Susumu Ohno
      Pages 39-49

    6. The Developmental Strategy of Competitive Displacements and the Role of ฮฒ2-Microglobulin-H-2 or HLA Dimers in Organogenesis

      • Susumu Ohno
      Pages 50-66

    7. Testis-Organizing H-Y Antigen and the Cell Lineage-Specific Antigen of Testicular Sertoli and Ovarian Follicular Cells: H-2 Restricted and Nonrestricted Killing by Female T-Cells of Testicular Sertoli Cells

      • Susumu Ohno
      Pages 67-78

    8. Why Are a Number of Unlinked Genes Involved in H-Y Antigen Expression ?

      • Susumu Ohno
      Pages 79-87

  4. Nuclear-Cytosol Androgen-Receptor Protein and Hormonal Secondary (Extragonadal) Sex Determination

    1. Front Matter

      Pages 89-89
      Download chapter PDF

    2. The Inherently Feminine Embryonic Plan and Testosterone Induction of the Male Secondary Sex

      • Susumu Ohno
      Pages 91-103

    3. Abolition of All Adrogen Target Organ Responses by the X-Linked Tfm (Testicular Feminization) Mutation

      • Susumu Ohno
      Pages 104-116

    4. The Tfm Mutation Affects the Nuclear-Cytosol Androgen-Receptor Protein

      • Susumu Ohno
      Pages 117-128

  5. Back Matter

    Pages 129-142
    Download chapter PDF
Back to top

Keywords

About this book

Upon wresting the control of the earth from the Titans, Zeus assigned the task of creating living creatures to two Titan brothers who had sided with him in the epic battle just concluded. Because Epimetheus, who had been endowed only with hindsight, had the first hand in this creation, all the good attributes were exhausยญ ted by the time the lion, the elephant and other animals were created. When the time came for the creation of man, there were precious few materials left to work with. Not surprisingly, man was made weak and naked. Prometheus took pity on this miscreation and gave man the use of fire. For this foresight, Zeus meted out horrible punishment, binding Prometheus to a rocky pillar in the Caucasas Mounยญ tains and letting a vulture consume his liver daily. It seems to me that the ancient Greeks in their unfathomable wisdom underยญ stood the essence of the evolutionary process very well. Had Escherichia coli of 200 million years or so ago been endowed with the foresight to anticipate the eventual emergence of and subsequent dominance by mammals of this Earth, they would no doubt have equipped themselves, in anticipation of the coming cerยญ tainty, with the lac operon to deal with lactose in the suckling mammalian infant's gut. Had they been able to do so, the actual emergance of mammals would have exerted no selective pressure upon existing E. COLI.

Authors and Affiliations

  • Department of Biology, City of Hope, National Medical Center, USA

    Susumu Ohno

Bibliographic Information

  • Book Title: Major Sex-Determining Genes

  • Authors: Susumu Ohno

  • Series Title: Monographs on Endocrinology

  • DOI: https://doi.org/10.1007/978-3-642-81261-3

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin ยท Heidelberg 1979

  • Softcover ISBN: 978-3-642-81263-7Published: 15 December 2011

  • eBook ISBN: 978-3-642-81261-3Published: 08 March 2013

  • Series ISSN: 0077-1015

  • Edition Number: 1

  • Number of Pages: XIV, 142

  • Number of Illustrations: 10 b/w illustrations

  • Topics: Human Genetics, Endocrinology

  • Industry Sectors: Biotechnology, Pharma

Publish with us

Policies and ethics

Back to top

Search

Navigation