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Role of Gnotobiotic Care in Chemotherapy of Acute Leukemia

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Complications of Cancer Chemotherapy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 49))

Abstract

Success in prolonging the survival of patients with acute leukemia (AL) is not attributed solely to application of chemotherapy but also to improved supportive care. Severe and often fatal infection remains a problem during induction of remission by chemotherapy. The difficulty in treating infections during the phase is due not only to the marked granulocytopenia resulting from bone marrow depletion but also to the fact that microorganisms normally present in the environment or the endogenous microflora may become pathogenic under these conditions. The aim of gnotobiotic care is to prevent infection by pathogens and potential pathogens.

Supported by Deutsche Forschungsgemeinschaft, Sonderforschungsbereich 112, Zellsystemphysiologie.

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References

  • Dietrich,M.,Rasche, H., Rommel,K., Hochapfel, G.: Antimicrobial therapy as a part of the decontamination procedures for patients with acute leukemia. Europ. J. Cancer 9, 443 (1973).

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  • MathÉ, G. (ed.): Aseptic environments and cancer treatment. In Recent Results in Cancer Research. Vol. 29. Springer: Berlin, Heidelberg, New York 1970.

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Author information

Authors and Affiliations

  1. Center for Internal Medicine and Pediatrics Division of Hematology, University of Ulm, Ulm, Germany

    M. Dietrich

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  1. M. Dietrich
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Editor information

Editors and Affiliations

  1. Institut de Cancérologie et d’Immunogénétique, Hôpital Paul-Brousse, F-94, Villejuif, France

    Georges Mathé (Professor) (Professor)

  2. Cellular and Tumor Immunology Section Department of Health, Education and Welfare, N.I.H., 20014, Bethesda, MD, USA

    Robert K. Oldham M. D.

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© 1974 Springer-Verlag Berlin · Heidelberg

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Dietrich, M. (1974). Role of Gnotobiotic Care in Chemotherapy of Acute Leukemia. In: Mathé, G., Oldham, R.K. (eds) Complications of Cancer Chemotherapy. Recent Results in Cancer Research, vol 49. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80848-7_7

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  • DOI: https://doi.org/10.1007/978-3-642-80848-7_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80850-0

  • Online ISBN: 978-3-642-80848-7

  • eBook Packages: Springer Book Archive

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