Complications of Cancer Chemotherapy

  • Georges Mathé
  • Robert K. Oldham

Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 49)

Table of contents

  1. Front Matter
    Pages I-VI
  2. G. Mathé, R. K. Oldham
    Pages 1-2
  3. L. M. van Putten
    Pages 15-19
  4. V. Rodriguez, G. P. Bodey, E. J. Freireich
    Pages 24-28
  5. C. Jasmin, F. Bricout, J. M. Huraux, R. Weiner, R. K. Oldham, G. Mathé
    Pages 29-33
  6. A. Bussel, M. Benbunan, M. Weil, J. Reviron, C. Jacquillat, M. Boiron et al.
    Pages 40-47
  7. H.-P. Lohrmann, M. I. Bull, J. A. Decter, R. A. Yankee, R. G. Graw Jr.
    Pages 48-55
  8. C. Griscelli, H. Betuel, C. Herzog, J. L. Touraine, J. P. Revillard
    Pages 61-73
  9. A. Khan, J. M. Hill, E. Loeb, A. MacLellan, N. O. Hill
    Pages 74-80
  10. F. Spreafico, M. G. Donelli, A. Vecchi, A. Bossi, S. Garattini
    Pages 88-94
  11. I. Bartošek, M. G. Donelli, A. Guaitani
    Pages 95-100
  12. G. P. Canellos, V. T. de Vita, J. C. Arseneau, R. C. Johnson
    Pages 108-114
  13. D. Belpomme, P. Carde, R. K. Oldham, G. Mathé, C. Jacquillat, N. Chelloul et al.
    Pages 115-123

About this book

Introduction

G. MATHE and R. K. OLDHAM'~ Institut de Cancerologie et d'Immunogem!tique, Hopital Paul Brousse, Villejuif Since the last war, cancer chemotherapy has been the object of very intensive and expensive research. Nevertheless, its development has been very slow, and its ultimate potential is today somewhat in doubt. In doubt because it does not cure any cancer patients except a) females carrying placental choriocarcinoma, a semi-allogenic tumor, in which case, cure may be in­ fluenced by immune rejection, and b) children suffering from Burkitt's tumor, where the probable reason for the cure is that all the neoplastic cells are in the cycle, which is a unique condition among all the human tumor varieties. Whether the long term survivors in acute leukemia, lymphomas, certain sarcomas and certain testicular tumors are "cures" will require longer follow-up. The idea that chemotherapy does not cure most cancer patients because all their neoplastic cells are not in cycle has led to the use of drug combinations. Whatever they are, "cocktail combinations" which are made up of drugs given according to any timing, or scientific combinations, based on pharmacodynamics, pharmaco­ kinetics or cell kinetics data, are more toxic than single drugs, and are all the more toxic as the number of drugs in the combination is increased.

Keywords

cancer carcinoma cell leukemia lymphoma neoplasm therapy tumor

Editors and affiliations

  • Georges Mathé
    • 1
  • Robert K. Oldham
    • 2
  1. 1.Institut de Cancérologie et d’ImmunogénétiqueHôpital Paul-BrousseVillejuifFrance
  2. 2.Cellular and Tumor Immunology Section Department of Health, Education and WelfareN.I.H.BethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-80848-7
  • Copyright Information Springer-Verlag Berlin Heidelberg 1974
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-80850-0
  • Online ISBN 978-3-642-80848-7
  • Series Print ISSN 0080-0015
  • About this book
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