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Hematological Toxicity: Biological Basis

  • L. M. van Putten
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 49)

Abstract

A shortage of leukocytes and platelets may be treated by transfusions, as will be discussed by others. A search for a more efficient treatment or prevention of haemopoietic failure after chemotherapy has not yielded a better treatment. Autologous bone marrow transplantation after single high dose cytostatic therapy was not a successful method to combat toxicity. The biological basis of bone marrow toxicity should be studied in more detail to find better means to combat it. A retrospective look for the reason why bone marrow transplantation failed, indicates that stem cell loss was not the cause of death after single dose chemotherapy. Animal studies confirm, that X-ray lethality but not the mortality after chemotherapy may be prevented by stem cell replacement.

Keywords

Stem Cell Bone Marrow Transplantation Nitroso Urea Cytostatic Drug Cytostatic Agent 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Abbreviations

VCR

Vincristine

VLB

Vinblastine

BCNU1

Bis-Chloro-aethyl Nitroso Urea

Myl2

Myleran (Busulfan)

Iso3

Isophosphamide

MUST

Mechlorethamine

Trilo3

Trilophosphamide

CCNU1

Cyclohexyl-Chloroethyl-Nitroso Urea

Nor-M

Bis-chloro-ethylamine

TEM5

Triethylene Melamine

ACA6

Aminochlorambucil

MCCNU1

Methyl-Cyclohexyl-Chloroethyl Nitroso Urea

Cyclo3

Cyclophosphamide

DAHM

Di-AnHydro-MannitoI7

DMM

DiMethyl-Myleran7

5FU4

5 Fluoro-Uracil

15 MeVN

15 MeV neutron irradiation

Melph

Melphalan

X

300 keV X-rays.

CFU

haemopoietic spleen colony forming stem cell

3HTdR

tritiated thymidine (9 Ci/mMol.)

VM26

4-demethyl-epipodophyllotoxin-thenylidene glucoside, supplied by Sandoz

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References

  1. BekkumD. W. van: Foreign bone marrow transplantation following fractionated wholebody irradiation in mice. In: Radiation effects in physics, chemistry and biology, p. 362 (Ed.: M. Ebert and A. Howard), Amsterdam: North Holland Publishing Co. 1963.Google Scholar
  2. Bruce, D. L., Lin, H. S., Bruce,W. R.: Reduction of colony-forming cell sensitivity to arabinyl cytosine by halothane anaesthesia. Cancer Res. 30, 1803 (1970).PubMedGoogle Scholar
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  4. Byron, J. W.: Drug receptors and the haemopoietic stem cell. Nature New Biol. 241, 152 (1973).PubMedGoogle Scholar
  5. Putten L. M. van, Lelieveld, P., Kram-idsengaL. K. J.: Cell-cycle specificity and therapeutic effectiveness of cytostatic agents. Cancer Chemother. Reports Part 1, 56, 6 (1972).Google Scholar

Copyright information

© Springer-Verlag Berlin · Heidelberg 1974

Authors and Affiliations

  • L. M. van Putten
    • 1
  1. 1.Radiobiological Institute TNORijswijkThe Netherlands

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