Hematological Toxicity: Biological Basis
A shortage of leukocytes and platelets may be treated by transfusions, as will be discussed by others. A search for a more efficient treatment or prevention of haemopoietic failure after chemotherapy has not yielded a better treatment. Autologous bone marrow transplantation after single high dose cytostatic therapy was not a successful method to combat toxicity. The biological basis of bone marrow toxicity should be studied in more detail to find better means to combat it. A retrospective look for the reason why bone marrow transplantation failed, indicates that stem cell loss was not the cause of death after single dose chemotherapy. Animal studies confirm, that X-ray lethality but not the mortality after chemotherapy may be prevented by stem cell replacement.
KeywordsStem Cell Bone Marrow Transplantation Nitroso Urea Cytostatic Drug Cytostatic Agent
Bis-Chloro-aethyl Nitroso Urea
Methyl-Cyclohexyl-Chloroethyl Nitroso Urea
- 15 MeVN
15 MeV neutron irradiation
300 keV X-rays.
haemopoietic spleen colony forming stem cell
tritiated thymidine (9 Ci/mMol.)
4-demethyl-epipodophyllotoxin-thenylidene glucoside, supplied by Sandoz
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