Abstract
A shortage of leukocytes and platelets may be treated by transfusions, as will be discussed by others. A search for a more efficient treatment or prevention of haemopoietic failure after chemotherapy has not yielded a better treatment. Autologous bone marrow transplantation after single high dose cytostatic therapy was not a successful method to combat toxicity. The biological basis of bone marrow toxicity should be studied in more detail to find better means to combat it. A retrospective look for the reason why bone marrow transplantation failed, indicates that stem cell loss was not the cause of death after single dose chemotherapy. Animal studies confirm, that X-ray lethality but not the mortality after chemotherapy may be prevented by stem cell replacement.
Parts of the work were carried out in programs of the EORTC Stem Cell Club and the EORTC Screening Pharmacology Group.
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Abbreviations
- VCR:
-
Vincristine
- VLB:
-
Vinblastine
- BCNU1 :
-
Bis-Chloro-aethyl Nitroso Urea
- Myl2 :
-
Myleran (Busulfan)
- Iso3 :
-
Isophosphamide
- MUST:
-
Mechlorethamine
- Trilo3 :
-
Trilophosphamide
- CCNU1 :
-
Cyclohexyl-Chloroethyl-Nitroso Urea
- Nor-M:
-
Bis-chloro-ethylamine
- TEM5 :
-
Triethylene Melamine
- ACA6 :
-
Aminochlorambucil
- MCCNU1 :
-
Methyl-Cyclohexyl-Chloroethyl Nitroso Urea
- Cyclo3 :
-
Cyclophosphamide
- DAHM:
-
Di-AnHydro-MannitoI7
- DMM:
-
DiMethyl-Myleran7
- 5FU4 :
-
5 Fluoro-Uracil
- 15 MeVN:
-
15 MeV neutron irradiation
- Melph:
-
Melphalan
- X:
-
300 keV X-rays.
- CFU:
-
haemopoietic spleen colony forming stem cell
- 3HTdR:
-
tritiated thymidine (9 Ci/mMol.)
- VM26:
-
4-demethyl-epipodophyllotoxin-thenylidene glucoside, supplied by Sandoz
References
BekkumD. W. van: Foreign bone marrow transplantation following fractionated wholebody irradiation in mice. In: Radiation effects in physics, chemistry and biology, p. 362 (Ed.: M. Ebert and A. Howard), Amsterdam: North Holland Publishing Co. 1963.
Bruce, D. L., Lin, H. S., Bruce,W. R.: Reduction of colony-forming cell sensitivity to arabinyl cytosine by halothane anaesthesia. Cancer Res. 30, 1803 (1970).
Byron, J. W.: Evidence for adrenergic receptor initiating DNA synthesis in haemopoietic stem cells. Exp. Cell Res. 71, 228 (1972).
Byron, J. W.: Drug receptors and the haemopoietic stem cell. Nature New Biol. 241, 152 (1973).
Putten L. M. van, Lelieveld, P., Kram-idsengaL. K. J.: Cell-cycle specificity and therapeutic effectiveness of cytostatic agents. Cancer Chemother. Reports Part 1, 56, 6 (1972).
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© 1974 Springer-Verlag Berlin · Heidelberg
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van Putten, L.M. (1974). Hematological Toxicity: Biological Basis. In: Mathé, G., Oldham, R.K. (eds) Complications of Cancer Chemotherapy. Recent Results in Cancer Research, vol 49. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80848-7_3
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DOI: https://doi.org/10.1007/978-3-642-80848-7_3
Publisher Name: Springer, Berlin, Heidelberg
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