Hematological Toxicity: Biological Basis

  • L. M. van Putten
Part of the Recent Results in Cancer Research book series (RECENTCANCER, volume 49)

Abstract

A shortage of leukocytes and platelets may be treated by transfusions, as will be discussed by others. A search for a more efficient treatment or prevention of haemopoietic failure after chemotherapy has not yielded a better treatment. Autologous bone marrow transplantation after single high dose cytostatic therapy was not a successful method to combat toxicity. The biological basis of bone marrow toxicity should be studied in more detail to find better means to combat it. A retrospective look for the reason why bone marrow transplantation failed, indicates that stem cell loss was not the cause of death after single dose chemotherapy. Animal studies confirm, that X-ray lethality but not the mortality after chemotherapy may be prevented by stem cell replacement.

Keywords

Methotrexate Cyclophosphamide Cytosine Halothane Vincristine 

Abbreviations

VCR

Vincristine

VLB

Vinblastine

BCNU1

Bis-Chloro-aethyl Nitroso Urea

Myl2

Myleran (Busulfan)

Iso3

Isophosphamide

MUST

Mechlorethamine

Trilo3

Trilophosphamide

CCNU1

Cyclohexyl-Chloroethyl-Nitroso Urea

Nor-M

Bis-chloro-ethylamine

TEM5

Triethylene Melamine

ACA6

Aminochlorambucil

MCCNU1

Methyl-Cyclohexyl-Chloroethyl Nitroso Urea

Cyclo3

Cyclophosphamide

DAHM

Di-AnHydro-MannitoI7

DMM

DiMethyl-Myleran7

5FU4

5 Fluoro-Uracil

15 MeVN

15 MeV neutron irradiation

Melph

Melphalan

X

300 keV X-rays.

CFU

haemopoietic spleen colony forming stem cell

3HTdR

tritiated thymidine (9 Ci/mMol.)

VM26

4-demethyl-epipodophyllotoxin-thenylidene glucoside, supplied by Sandoz

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References

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Copyright information

© Springer-Verlag Berlin · Heidelberg 1974

Authors and Affiliations

  • L. M. van Putten
    • 1
  1. 1.Radiobiological Institute TNORijswijkThe Netherlands

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