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Application of Large Animal Toxicology to the Qualitative and Quantitative Predication of Drug Toxicity in Man

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Complications of Cancer Chemotherapy

Part of the book series: Recent Results in Cancer Research ((RECENTCANCER,volume 49))

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Abstract

In the preclinical stage of drug development, the most crucial correlation of data obtained in animals with the expected effects in man is in the area of toxicology. It is the preclinical toxicologic evaluation of a new drug that enables the clinician to initiate clinical trial with a reasonable assurance of a safety margin for his patients.

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References

  • Freireich, E.J., Gehan, E.A., Rall, D. P., Schmidt, L. H., Skipper, H. E.: Quantitative comparison of toxicity of anticancer agents in mouse, rat, hamster, dog, monkey, and man. Cancer Chemother. Rep. 50, 219 (1966).

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  • Griswold, D. P., Laster, W. R., Snow, M. Y., Schabel, F. M., Skipper, H. E.: Experimental evaluation of potential anticancer agents. XII Quantitative drug response of Sa 180, Ca 755, and leukemia L1210 system to a “standard list” of “active” and “inactive” agents. Cancer Res. (supp. part 2) 23, 271 (1963).

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  • Schein, P. S., Davis, R. D., Carter, S. K., Newman, J., Schein, D. R., Rall, D. P.: The evaluation of anticancer drugs in dogs and monkeys for the prediction of qualitative toxicities in man. Clin. Pharmacol, and Ther. 11, 3 (1970).

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Author information

Authors and Affiliations

  1. National Cancer Institute, N.I.H, Bethesda, MD, USA

    S. K. Carter

Authors
  1. S. K. Carter
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Editor information

Editors and Affiliations

  1. Institut de Cancérologie et d’Immunogénétique, Hôpital Paul-Brousse, F-94, Villejuif, France

    Georges Mathé (Professor) (Professor)

  2. Cellular and Tumor Immunology Section Department of Health, Education and Welfare, N.I.H., 20014, Bethesda, MD, USA

    Robert K. Oldham M. D.

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© 1974 Springer-Verlag Berlin · Heidelberg

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Carter, S.K. (1974). Application of Large Animal Toxicology to the Qualitative and Quantitative Predication of Drug Toxicity in Man. In: Mathé, G., Oldham, R.K. (eds) Complications of Cancer Chemotherapy. Recent Results in Cancer Research, vol 49. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-80848-7_2

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  • DOI: https://doi.org/10.1007/978-3-642-80848-7_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-80850-0

  • Online ISBN: 978-3-642-80848-7

  • eBook Packages: Springer Book Archive

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