Abstract
Our knowledge concerning mineral fibre induced disease has increased over the last few decades due to the intensive research effort in this area. Based upon expert clinical observations, extensive epidemiological studies and the use of experimental systems, there is now clear evidence that indicates the development of fibrosis or carcinogenesis is related to differences in overall dimensions, chemical composition and durability of the fibre in lung tissue (Liddell and Miller, 1991). However, the precise cellular and molecular events leading to the observed pathological changes remain to be elucidated. One of the most important areas that is now being investigated is the effect of man made mineral fibres (MMMF) on the development of pulmonary pathology. This is because these products are being introduced as replacements for asbestos based products and little human data is available.
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© 1994 Springer-Verlag Berlin Heidelberg
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Miller, K., Hudspith, B.N., Meredith, C. (1994). The effect of MMMF on the kinetics of cytokine expression in murine lung populations: Role in fibre-induced disease. In: Davis, J.M.G., Jaurand, MC. (eds) Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres. NATO ASI Series, vol 85. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-79041-6_7
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DOI: https://doi.org/10.1007/978-3-642-79041-6_7
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