Cellular and Molecular Effects of Mineral and Synthetic Dusts and Fibres

1. Front Matter

   Pages I-X

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2. Cellular and Metabolic Changes Cause by Mineral Dusts

   1. The Role of Active Oxygen Species in Uptake of Mineral Particles by Tracheobronchial Epithelial Cells

      • Andrew Churg

      Pages 1-8

   2. Oxygen Radical Generation by Asbestos and Its Correlation to Cytotoxicity

      • Val Vallyathan

      Pages 9-21

   3. Fiber-Induced Hydroxyl Radical Formation and DNA Damage

      • Neil F. Johnson, Kirk R. Maples

      Pages 23-37

   4. Involvement of the Oxidative Stress in the Toxicity of Iron-Containing Particles on Tracheal Epithelium in Primary Culture

      • Catherine Guilianelli, Armelle Baeza-Squiban, Odile Houcine, Henri Pezerat, Francelyne Marano

      Pages 39-51

   5. The Role of Iron in Asbestos-Induced Cancer

      • Ann E. Aust

      Pages 53-61

   6. Time-Lapse Video Light Microscopic and Electron Microscopic Observations of Vertebrate Epithelial Cells Exposed to Crocidolite Asbestos

      • C. G. Jensen, L. C. W. Jensen, J. G. Ault, G. Osorio, R. Cole, C. L. Rieder

      Pages 63-78

   7. The effect of MMMF on the kinetics of cytokine expression in murine lung populations: Role in fibre-induced disease

      • K. Miller, B. N. Hudspith, C. Meredith

      Pages 79-90

   8. The Second Messenger System in Diseases Caused by Mineral Dusts

      • J. A. Hoskins, R. C. Brown, C. E. Houghton, G. M. Brown

      Pages 91-108

   9. Transcriptional Regulation of IL-1ß and IL-6 by TNF-α in Asbestosis is Mediated by NF-IL6-like Motifs

      • Yihong Zhang, William N. Rom

      Pages 109-125

   10. Type II Epithelial Cell Proliferation and Surfactant Lipid Turnover in Silicosis

       • Raymond Bégin, Olivier Lesur, Boris Melloni

       Pages 127-139

   11. Role of Nitric Oxide Radicals in Asbestos-Induced Injury

       • George Thomas, Tasuke Ando, Kiran Verma, Elliott Kagan

       Pages 141-149

   12. Cytotoxicity and cell stimulating activity of ultrafine titanium dioxide

       • Mikko Holopainen, Kirsi Luoto

       Pages 151-158

   13. Carcinogenic Effects in Rats of Exposure to Different Minerals from Metallic Mine Ores, Radon and Radon Daughters

       • G. Monchaux, J. P. Morlier, M. Morin, R. Zalma, H. Ogata, H. Pézerat et al.

       Pages 159-164

   14. Biological Effects of a New Type of Pure Carbon (Fullerenes) in vitro

       • Thomas Baierl, Elisabeth Drosselmeyer, Arnulf Seidel

       Pages 165-169

3. Molecular Changes and DNA Alterations Produced by Mineral Dusts

   1. Augmentation in the Differential Oxidative DNA-Damage by Asbestos in Presence of H2O2 and Organic Peroxide/Hydroperoxide

      • Q. Rahman, N. Mahmood, S. G. Khan, M. Athar

      Pages 171-181

   2. In Vitro DNA and Chromosome Damage Produced by Some Minerals and Man Made Particles on Rat Pleural Mesothelial Cells (RPMC) — Mechanisms and Relationship with in Vivo Experimental Findings

      • M. C. Jaurand, M. Yegles, H. Y. Dong, A. Renier, L. Saint Etienne, L. Kheuang et al.

      Pages 183-192

   3. Evaluation of Proinflammatory Cytokine Expression in Alveolar Macrophages and in the Lung of Pneumoconiotic Patients

      • D. Vanhée, P. Gosset, B. Wallaert, C. Voisin, A. B. Tonnel

      Pages 193-204

   4. Activation of Early Cellular Responses by Asbestos: Induction of c-FOS and c-JUN Protooncogene Expression in Rat Pleural Mesothelial Cells

      • Yvonne Janssen, Joanne Marsh, Timothy Quinlan, Cindy Timblin, Kelly BéruBé, Lois Jimenez et al.

      Pages 205-213

   5. Molecular Alterations in Murine Mesotheliomas Induced by Crocidolite Asbestos

      • V. D. Moyer, C. A. Vaslet, A. B. Kane

      Pages 215-220

Presented here are recent data on the mechanisms of action of different dusts and fibres of industrial interest. Emphasis is placed on the use of cell and organ culture and lavage cell populations obtained from man and laboratory animals to elucidate cellular and molecular events occurring after their interaction with fibrous and non-fibrous particulates including metal compounds. In four sections, the volume provides research findings in the following areas: - Cellular and Metabolic Changes Caused by Mineral Dusts - Molecular Changes and DNA Alterations Produced by Mineral Dusts - In Vivo Dust-Related Pathological Processes. Correlations Between in Vitro and in Vivo Data - Physico-Chemical Properties of Minerals in Relation to Their Biological Effects.

• Asbest
• Asbestos
• Dusts
• Fasern
• Fibres
• Staub
• Toxicology
• Toxikologie
• Vivo
• ecotoxicology

• Institute of Occupational Medicine, Edinburgh, Scotland

  John M. G. Davis

• Unité 139 CHU Henri Mondor, INSERM, Creteil, Cedex, France

  Marie-Claude Jaurand

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