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2′,5′-0ligoadenylate Synthetase in Autoimmune BB Rats

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Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 14))

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Abstract

In 1974, Wistar rats in the colony of Bio Breeding Laboratories in Worcester, Massachusetts, developed signs of insulin-dependent diabetes (IDDM) (Logo-thetopoulos et al. 1984; Marliss et al. 1982). This syndrome is believed to be a cell-mediated autoimmune process that selectively destroys the insulin producing β-cells in the islets of Langerhans in the pancreas. Throughout the years many ingenious hypotheses have been created in order to explain the destructive process, but the triggering event still remains elusive. In the many attempts to understand the etiopathogenesis of IDDM great help has come from different animal models like the streptozotocin-treated mice, the NOD (nonobese diabetic) mice, and the spontaneously diabetic BB rat.

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Authors and Affiliations

  1. Dept. of Medical Microbiology, Institute of Medical Biology, University of Odense, Winsløwparken 19, DK-5000, Odense C, Denmark

    V. Bonnevie-Nielsen

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  1. V. Bonnevie-Nielsen
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  1. Institut für Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universität Mainz, Duesbergweg 6, 55099, Mainz, Germany

    W. E. G. Müller  & H. C. Schröder  & 

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© 1994 Springer-Verlag Berlin Heidelberg

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Bonnevie-Nielsen, V. (1994). 2′,5′-0ligoadenylate Synthetase in Autoimmune BB Rats. In: Müller, W.E.G., Schröder, H.C. (eds) Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates. Progress in Molecular and Subcellular Biology, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78549-8_11

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  • DOI: https://doi.org/10.1007/978-3-642-78549-8_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78551-1

  • Online ISBN: 978-3-642-78549-8

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