Biological Response Modifiers — Interferons, Double-Stranded RNA and 2′,5′-Oligoadenylates

1. Front Matter

   Pages I-XV

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2. Activation of the dsRNA-Dependent Kinase

   • R. A. Petryshyn, J. Li, R. Judware

   Pages 1-14

3. Double-Stranded RNAs as Gene Activators

   • S. Landolfo, M. Gariglio, G. Gribaudo, G. Garotta

   Pages 15-27

4. Viral-Dependent Phosphorylation of a dsRNA-Dependent Kinase

   • D. A. Roth, X. He

   Pages 28-47

5. Cellular Inhibitors of the Interferon-Induced, dsRNA-Activated Protein Kinase

   • T. G. Lee, M. G. Katze

   Pages 48-65

6. Mechanism of the Antiretroviral Effect of dsRNA

   • W. E. G. Müller, H. Ushijima, H. C. Schröder

   Pages 66-88

7. The Antiviral Activity of RNA-Dye Combinations

   • J. M. Jamison, J. Gilloteaux, J. L. Summers

   Pages 89-113

8. Chemical Synthesis of 2′,5′-0ligoadenylate Analogues

   • R. Charubala, W. Pfleiderer

   Pages 114-138

9. Homologies Between Different Forms of 2-5A Synthetases

   • E. Truve, M. Kelve, A. Aaspollu, H. C. Schröder, W. E. G. Müller

   Pages 139-149

10. 2-5A and Virus Infection

    • N. Fujii

    Pages 150-175

11. The 2-5A System and HIV Infection

    • H. C. Schröder, M. Kelve, W. E. G. Müller

    Pages 176-197

12. 2′,5′-0ligoadenylate Synthetase in Autoimmune BB Rats

    • V. Bonnevie-Nielsen

    Pages 198-208

13. Oligoadenylate and Cyclic AMP: Interrelation and Mutual Regulation

    • A. V. Itkes

    Pages 209-221

14. Regulation of HIV Replication in Monocytes by Interferon

    • J. A. Turpin, S. X. Fan, B. D. Hansen, M. L. Francis, L. M. Baca-Regen, H. E. Gendelman et al.

    Pages 222-241

15. Transmembrane Signaling by IFN-α

    • L. M. Pfeffer, S. N. Constantinescu, C. Wang

    Pages 242-259

16. Photolabeling of the Enzymes of the 2-5A Synthetase/RNase L/p68 Kinase Antiviral Systems with Azido Probes

    • R. J. Suhadolnik

    Pages 260-275

Biological response modifiers are increasingly used in viral and cancer therapy. Since alterations of the immune system are the primary symptoms of HIV infection, especially therapies directed towards the modulation of the immune response have been under intense evaluation. This volume summarizes current knowledge of the interferon-based natural antiviral protection system including 2',5'-oligoadenylate and double-stranded RNA. It will also help to develop further a solid scientific rationale for the practical use of heterologous immunomodulators in the clinics.

• Doppelstrang-RNA
• HIV
• Immunantwort
• RNA
• Virusinfektion
• Zytokine
• cancer
• cancer therapy
• cytokine
• cytokines
• immune response
• immune system
• infection
• infections
• interferon

• Institut für Physiologische Chemie, Abteilung Angewandte Molekularbiologie, Universität Mainz, Mainz, Germany

  W. E. G. Müller, H. C. Schröder

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