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Transcriptional, Posttranscriptional, and Posttranslational Regulation of G-Proteins and Adrenergic Receptors

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GTPases in Biology II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 108 / 2))

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Abstract

Transmembrane signaling via G-protein-linked pathways is regulated dynamically. Catecholamines regulate fundamental physiological pathways, such as respiration, cardiac rate, and lipolysis. Consequently, adrenergic receptors and their G-protein partners through which adenylyl cyclase, phospholipase C, and other effectors are controlled have been adopted as models for intensive study of the regulation of G-protein-mediated pathways. The epertoire of mechanisms for regulation includes transcriptional, posttransriptional, and posttranslational components. Acute, short-term (seconds to minutes) regulation, typified by agonist-induced desensitization, virtually precludes significant transcriptional and posttranscriptional components which are capable of changing steady-state mRNA levels and thereby protein expression. Posttranslational mechanisms, such as protein phosphorylatiion, are most prominent in the acute phases, whereas longer term (hours) regulation may include transcriptional, posttranscriptional, as well as posttranslational components (Hausdorff et al. 1990). Both receptors (George et al. 1988) and G-proteeins (Rapiejko et al. 1989) have been shown to be the locus of physiological regulation at which an entire pathway can be influenced. Furthermore, G-protein-linked pathways do not operate in isolation and are subject not only to agonist-induced homologous regulation but also to heterologous regulation by ligands operating via other G-protein-linked pathways, gene regulaation (steroids, retinoids), and/or tyrosine kinases (insulin and growth factors). This chapter highlights mechanisms by which G-protein-mediated pathways are regulated , drawing heavily upon our knowledge of adrenergic receptor-mediated responses.

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Authors
  1. J. R. Hadcock
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  2. C. C. Malbon
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Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Department of Medicine Cell Biology and Experimental Therapeutics, Houston VA Medical Center, Room 3C-385, 2002 Holcombe Boulevard, Houston, TX, 77030, USA

    Burton F. Dickey M.D.

  2. Department of Cell Biology, Molecular Physiology and Biophysics, Medicine and Neurosciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    Lutz Birnbaumer Ph.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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Hadcock, J.R., Malbon, C.C. (1993). Transcriptional, Posttranscriptional, and Posttranslational Regulation of G-Proteins and Adrenergic Receptors. In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology II. Handbook of Experimental Pharmacology, vol 108 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78345-6_8

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  • DOI: https://doi.org/10.1007/978-3-642-78345-6_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78347-0

  • Online ISBN: 978-3-642-78345-6

  • eBook Packages: Springer Book Archive

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