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G-Proteins in the Signal Transduction of the Neutrophil

  • Chapter
GTPases in Biology II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 108 / 2))

Abstract

Heterotrimeric G protein-mediated transmembrane signaling has been extensively studied in polymorphonuclear leukocytes (PMNs), due in part to the ability to obtain large numbers of these cells from peripheral blood and their importance to health. Studies using PMNs and the human cell line HL-60 have produced significant advances in understanding the molecular mechanisms of PMN responses to infection and inflammation. Additionally, these cells provide a useful model for studying the coupling of multiple receptors to multiple effectors by G-proteins.

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Authors
  1. K. R. McLeish
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  2. K. H. Jakobs
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Editor information

Editors and Affiliations

  1. Baylor College of Medicine, Department of Medicine Cell Biology and Experimental Therapeutics, Houston VA Medical Center, Room 3C-385, 2002 Holcombe Boulevard, Houston, TX, 77030, USA

    Burton F. Dickey M.D.

  2. Department of Cell Biology, Molecular Physiology and Biophysics, Medicine and Neurosciences, Baylor College of Medicine, One Baylor Plaza, Houston, TX, 77030, USA

    Lutz Birnbaumer Ph.D.

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© 1993 Springer-Verlag Berlin Heidelberg

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McLeish, K.R., Jakobs, K.H. (1993). G-Proteins in the Signal Transduction of the Neutrophil. In: Dickey, B.F., Birnbaumer, L. (eds) GTPases in Biology II. Handbook of Experimental Pharmacology, vol 108 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78345-6_23

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  • DOI: https://doi.org/10.1007/978-3-642-78345-6_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78347-0

  • Online ISBN: 978-3-642-78345-6

  • eBook Packages: Springer Book Archive

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