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Use of Transgenic and Genetic Models to Study the Neuroendocrine Regulation of Growth Hormone Secretion

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Growth Hormone and Somatomedins during Lifespan

Abstract

The neuroendocrine regulation of growth hormone (GH) has been extensively studied in many species, including humans. Although experiments in intact animals and after destruction or removal of key components of the hypothalamic-GH-IGF-I axis have given considerable insight into the individual components, the ablative procedures all give rise to other neuronal and/or hormonal deficiencies that complicate interpretation of the results. The recent availability of numerous models, both genetic and transgenic, has provided the opportunity to study selective perturbations of the axis and to examine the effects of excessive or diminished secretion and/or action of several individual hormonal components. This manuscript will review the experience in the authors’ laboratory using several transgenic and genetic strains of mice and rats with altered function of the individual axis components. These functional changes all produce profound effects on growth as well as on other components of the hypothalamic-pituitary axis.

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Authors
  1. L. A. Frohman
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  2. T. R. Downs
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  3. M. Sato
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Editor information

Editors and Affiliations

  1. Department of Pharmacology, School of Medicine, University of Milan, Via Vanvitelli 32, 20129, Milan, Italy

    Eugenio E. Müller (Professor of Pharmacology) & Vittorio Locatelli (Associate Professor of Pharmacology) (Professor of Pharmacology) &  (Associate Professor of Pharmacology)

  2. Pharmaco-biological Institute, University of Bari, 70125, Bari, Italy

    Daniela Cocchi (Professor of Pharmacology) (Professor of Pharmacology)

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© 1993 Springer-Verlag Berlin Heidelberg

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Frohman, L.A., Downs, T.R., Sato, M. (1993). Use of Transgenic and Genetic Models to Study the Neuroendocrine Regulation of Growth Hormone Secretion. In: MĂĽller, E.E., Cocchi, D., Locatelli, V. (eds) Growth Hormone and Somatomedins during Lifespan. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-78217-6_12

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  • DOI: https://doi.org/10.1007/978-3-642-78217-6_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-78219-0

  • Online ISBN: 978-3-642-78217-6

  • eBook Packages: Springer Book Archive

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