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Application of Mathematical Dose-Response Models vs. Physiological Models in Risk Assessment in Reproductive Toxicology

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Risk Assessment of Prenatally-Induced Adverse Health Effects

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Abstract

Risk assessment in reproductive toxicology is amenable to both mathematical and physiological modelling techniques. These two methods are not necessarily mutually exclusive and can be complementary in achieving the goals of risk assessment. In this presentation examples of the use of the two approaches with data from studies undertaken in this laboratory are used to exemplify the two approaches.

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References

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Authors
  1. G. A. de S. Wickramaratne
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Editor information

Editors and Affiliations

  1. Institut für Toxikologie und Embryopharmakologie, Universitätsklinikum Rudolf Virchow, Freie Universität Berlin, Garystrasse 5, W-1000, Berlin 33, Germany

    Diether Neubert

  2. Developmental Toxicology Division, US Environmental Protection Agency, Health Effects Research Laboratory (MD-71), Research Triangle Park, NC, 27711, USA

    Robert J. Kavlock (Director) (Director)

  3. Institut für Anatomie, Freie Universität Berlin, Königin-Luise-Strasse 15, W-1000, Berlin 33, Germany

    Hans-Joachim Merker

  4. Institut für Toxikologie und Embryopharmakologie, Freie Universität Berlin, Garystrasse 5, W-1000, Berlin 33, Germany

    Jane Klein

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© 1992 Springer-Verlag Berlin Heidelberg

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Wickramaratne, G.A.d.S. (1992). Application of Mathematical Dose-Response Models vs. Physiological Models in Risk Assessment in Reproductive Toxicology. In: Neubert, D., Kavlock, R.J., Merker, HJ., Klein, J. (eds) Risk Assessment of Prenatally-Induced Adverse Health Effects. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77753-0_21

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  • DOI: https://doi.org/10.1007/978-3-642-77753-0_21

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77755-4

  • Online ISBN: 978-3-642-77753-0

  • eBook Packages: Springer Book Archive

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