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New Approaches to Evaluating the Pulmonary Effects of Controlled Inhalation Exposures in Human Volunteers

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Part of the ILSI Monographs book series (ILSI MONOGRAPHS)

Abstract

The respiratory tract serves as a passive portal of entry for various inhaled gases (e.g., CO) and vapors (e.g., benzene, toluene, methanol) as well as a target organ for the toxicologic effects of certain reactive gases (e.g., O3) and inhaled particulate matter. I will limit my remarks to the latter class of air pollutants and discuss only effects on the respiratory system. Nevertheless, we should bear in mind the possibility that systemic as well as localized respiratory tract effects may be attributable to inhaled toxicants. My remarks will deal with some issues in experimental protocol development, with newer experimental techniques suitable for use in human subjects, and with the promise and pitfalls of in vitro toxicologic study of human cells. Most of my illustrations will come from ozone toxicology with which I have the greatest familiarity, but which I hope will be generalizable.

Keywords

  • Chronic Obstructive Pulmonary Disease
  • Respiratory Syncytial Virus
  • Human Bronchial Epithelial Cell
  • Ozone Exposure
  • Strontium Phosphate

These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© 1993 Springer-Verlag Berlin Heidelberg

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Bromberg, P.A. (1993). New Approaches to Evaluating the Pulmonary Effects of Controlled Inhalation Exposures in Human Volunteers. In: Mohr, U., Bates, D.V., Fabel, H., Utell, M.J. (eds) Advances in Controlled Clinical Inhalation Studies. ILSI Monographs. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77176-7_21

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  • DOI: https://doi.org/10.1007/978-3-642-77176-7_21

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