Summary
Transgenic rats harboring and expressing the mouse Ren-2 gene were constructed by pronuclear microinjection of fertilised oocytes. Two strains of hypertensive transgenic rats have been successfully established, one of which, TGR(mRen2)27, has been the subject of detailed investigation. These rats have been shown to exhibit extreme hypertension but have a suppressed circulating renin angiotensin system. The focus of the present study was to define those tissues which express the transgene and to determine which tissues may be involved in the pathogenesis of the hypertensive phenotype observed. From a survey of a wide range of tissues, the most active site of transgene expression was found to be the adrenal gland. However several other tissues were shown to express the transgene at significant levels, including the vasculature and segments of the gastrointestinal tract. These data will, in part, aid in the understanding of this new model of hypertension.
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Peters, J., Bader, M., Ganten, D., Mullins, J. (1991). Tissue Distribution of Ren-2 Expression in Transgenic Rats. In: Berg, K., Bulyzhenkov, V., Christen, Y., Corvol, P. (eds) Genetic Approaches to Coronary Heart Disease and Hypertension. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-76891-0_7
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DOI: https://doi.org/10.1007/978-3-642-76891-0_7
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