Genetic Approaches to Coronary Heart Disease and Hypertension

1. Front Matter

   Pages I-XIV

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2. Genetics of Hypertension – An Overview

   • A. G. Motulsky, W. Burke

   Pages 1-7

3. A Population Perspective for Genetics Research and Applications to Control Cardiovascular Disease in Utah

   • R. R. Williams, S. C. Hunt, S. J. Hasstedt, P. N. Hopkins, L. L. Wu, M. C. Schumacher et al.

   Pages 8-19

4. Cell Membrane Alteration in Primary Hypertension: An Evidence of Its Genomic Source

   • Y. V. Postnov

   Pages 20-26

5. Molecular Genetics and Familial Arterial Hypertension

   • F. Soubrier, X. Jeunemaître, B. Rigat, F. Cambien, P. Corvol

   Pages 27-37

6. Gene Mapping in Experimental Hypertension

   • T. W. Kurtz, L. Simonet, V. Křen, M. Pravenec

   Pages 38-59

7. Transgenic Mice and the Development of Animal Models and Resources for Hypertension Research

   • C. D. Sigmund, C. A. Jones, J. R. Fabian, C. Wu, C. M. Kane, M. K. Ellsworth et al.

   Pages 60-73

8. Tissue Distribution of Ren-2 Expression in Transgenic Rats

   • J. Peters, M. Bader, D. Ganten, J. Mullins

   Pages 74-80

9. Prediction of Hypertension and Stroke for Controlling Cardiovascular Diseases in Genetic Rat Models

   • Y. Yamori, Y. Nara, T. Nabika, K. Ikeda, K. Matsumoto

   Pages 81-97

10. An Overview of the Genetics of Coronary Heart Disease and Its Risk Factors

    • K. Berg

    Pages 98-109

11. Genetic Risk Factors for Coronary Heart Disease in the Japanese Population

    • H. Hamaguchi, S. Kikuchi, H. Yanagi, T. Matsunaga, Y. Yamanouchi, A. Nakagawa et al.

    Pages 110-126

12. Genetic Epidemiology of Ischemic Heart Disease and Arterial Hypertension

    • V. A. Koshechkin, C. B. Hudaiberdyev, V. A. Kabakova, S. V. Panin, T. A. Rozhkova, E. Y. Solovjova

    Pages 127-142

13. The Role of Lp(a) in Atherosclerosis

    • R. Lawn

    Pages 143-151

14. Liver-Directed Gene Therapy In the Treatment of Familial Hypercholesterolemia

    • J. M. Wilson, M. Grossman

    Pages 152-156

15. Back Matter

    Pages 157-159

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Cardiovascular diseases are the principal cause of mortality in many developed countries and are increasing in importance in developing countries where communicable diseases are being brought under control. It is estimated that coronary heart disease (CRD) and cerebrovascular diseases are responsible for between 40-50% of all deaths. Righ blood pressure is common in all industrialized societies and contributes importantly to CRD. It is well known that genetic factors play an important role in the etiology and pathogenes es of cardiovascular diseases and contribute to an individual's susceptibility or resistance to the disease. The application of modern genetic techniques has resulted in the identification of polymorphie markers that are involved in the normal regulation and function of the cardiovascular system. Many of these may contribute to the individual differences in the risk for CRD and hypertension. It is now known that several risk factors or protective factors with respect to cardiovascular diseases are strongly influenced by genes, and it is now possible to identify individual genes contributing to cardiovascular risk. A large bank of genetic knowledge relevant to CRD and hypertension has become available during the past years. As a result, it is now believed that CRD, for example, could be a good model for a feasibility study to determine a way by which preventive measures can be applied.

• arterial hypertension
• artery
• atherosclerosis
• cardiovascular
• cardiovascular system
• coronary heart disease
• gene therapy
• genes
• genetics
• heart
• heart disease
• hypertension
• molecular genetics
• stroke
• vascular disease

• Institute of Medical Genetics, UllevalHospital, University of Oslo, Oslo, Norway

  Kare Berg

• World Health Organization, Geneva 27, Switzerland

  Victor Bulyzhenkov

• Fondation IPSEN pour la Recherche, Thérapeutique, Paris Cedex, France

  Yves Christen

• INSERM Unit 36, Collège de France, Paris, France

  Pierre Corvol

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