Increase of TNF-α Serum Levels in Major Transplant-Related Complications of Human Bone Marrow Transplantation— Association with Acute Graft-Versus-Host Disease and Activation of Host Macrophages

  • E. Holler
  • H. J. Kolb
  • S. Liesenfeld
  • A. Möller
  • J. Kempeni
  • G. Chmel
  • W. Lehmacher
  • B. Gleixner
  • J. Mittermüller
  • C. Riedner
  • W. Wilmanns
Conference paper

Abstract

In human bone marrow transplantation (BMT) transplant-related mortality is a major problem even in low-risk patients (pts) and still occurs in about 25% to 35% of pts [1]. During the aplastic phase, endothelial leakage syndrome (ELS) and veno-occlusive disease (VOD) are the major transplant-related complications (TRC). After engraftment, infections, interstitial pneumonitis (IP), and acute graft-versus-host disease (aGvHD) are the main causes of death within the first 4 to 6 months following BMT [2–4].

Keywords

Toxicity Catheter Arthritis Lymphoma Leukemia 

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Copyright information

© Springer-Verlag, Berlin Heidelberg 1990

Authors and Affiliations

  • E. Holler
  • H. J. Kolb
  • S. Liesenfeld
  • A. Möller
  • J. Kempeni
  • G. Chmel
  • W. Lehmacher
  • B. Gleixner
  • J. Mittermüller
  • C. Riedner
  • W. Wilmanns

There are no affiliations available

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