Increase of TNF-α Serum Levels in Major Transplant-Related Complications of Human Bone Marrow Transplantation— Association with Acute Graft-Versus-Host Disease and Activation of Host Macrophages
In human bone marrow transplantation (BMT) transplant-related mortality is a major problem even in low-risk patients (pts) and still occurs in about 25% to 35% of pts . During the aplastic phase, endothelial leakage syndrome (ELS) and veno-occlusive disease (VOD) are the major transplant-related complications (TRC). After engraftment, infections, interstitial pneumonitis (IP), and acute graft-versus-host disease (aGvHD) are the main causes of death within the first 4 to 6 months following BMT [2–4].
KeywordsToxicity Catheter Arthritis Lymphoma Leukemia
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- 1.Zwaan FE, Gratwohl A, Hermans J et al. (1988) Transplant related mortality in leukemia. Report from the Leukemia Working Party 1988. Bone Marrow Transplant 3, 1:152–158Google Scholar
- 6.Storb R, Thomas ED (1985) Graft-versus-host disease in dog and man. The Seattle experience. Immunol Rev 88:215–237Google Scholar
- 8.Tracey KJ, Vlassara H, Cerami A (1989) Cachectin()tumour necrosis factor. Lancet; 1122–1126Google Scholar
- 10.Niederwieser D, Auböck J, Troppmair J et al. (1988) Role of interferon in the induction of acute graft-versus-host disease. Bone Morrow Transplantation 3, 1:134Google Scholar
- 11.Koscielnak E, Bruchelt G, Trenner J et al. (1987) Kinetics of restoration of interferon production after bone marrow transplantation in man. Bone Marrow Transplant 1:379–387Google Scholar
- 12.Gale RP, Sparkes RS, Golde DW (1978) Bone marrow origin of hepatic macrophages ( Kupffer Cells) in humans. Science 201:937–938Google Scholar