Cytokines in Hemopoiesis, Oncology, and AIDS

1. Front Matter

   Pages i-lvii

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2. Overview

   1. Front Matter

      Pages 1-1

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   2. Colony Stimulating Factors:Past and Future

      • D. Metcalf

      Pages 3-7

   3. Regulation of Hematopoietic Progenitor Cell Growth by Stimulating and Suppressing Cytokines

      • H. E. Broxmeyer

      Pages 9-13

   4. Cytokine Interactions in Normal and Malignant Hematopoiesis

      • N. A. Cicco, W. Oster, A. Lindemann, R. Mertelsmann, F. Herrmann

      Pages 15-25

3. Preclinical and In Vitro Data

   1. Front Matter

      Pages 27-27

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   2. Colony Stimulating Factors in Normal Hematopoiesis

      1. Screening the Sensitivity of Hematopoietic Progenitor Cells to Different Growth Factors. Potential Importance in Therapy Trials with Colony Stimulating Factors

         • K. Vehmeyer, T. Liersch, G. Krieger, J. H. Beyer, G. A. Nagel

         Pages 29-36

      2. Effect of Human Recombinant Interleukin-3 in Long-term Bone Marrow Culture

         • R. Haas, D. Schwarz, S. Hohaus, E. Ogniben, G. Wulf, W. Hunstein

         Pages 37-44

      3. Secretion of Colony-Stimulating Factor for Macrophages (M-CSF) and Granulocyte/Macrophages (GM-CSF) is Developmentally Regulated in Human Macrophages

         • C. Scheibenbogen, G. Zenke, B. Faggs, K. Motoyoshi, L. Kanz, H. Sawert et al.

         Pages 45-51

      4. Expression of the M-CSF/CSF-1 Gene in Normal Human Alveolar Macrophages

         • H. Kreipe, H. J. Radzun, K. Heidorn, J. Barth, M. R. Parwaresch

         Pages 53-58

      5. Surface Expression of Interleukin-2 Receptors and CD4 Molecules by Human Eosinophils is Induced by GM-CSF and IL-3

         • D. Riedel, M. Brach, R. Mertelsmann, F. Herrmann

         Pages 59-65

      6. Expression of Interleukin Receptors on Human Eosinophils, Basophils, and Mast Cells

         • P. Valent, J. Besemer, H. Stockinger, E. Liehl, P. Bettelheim

         Pages 67-71

      7. Chemiluminescence of Polymorphonuclear Leukocytes in Response to Interferons

         • M. Suttorp, U. Barzantny, M. Rister

         Pages 73-80

      8. Glycolysis and Amino Acid Incorporation in IL-3-Dependent Cell Lines

         • G. Reisbach, J. Ellwart, P. Dörmer

         Pages 81-83

      9. Fibroblast Colony Stimulating Activity of GM-CSF and IL-3 in Human Bone Marrow Cell Cultures

         • P. Valent, K. Geissler, P. Kalhs, P. Kier, P. Bettelheim

         Pages 85-89

      10. Chromatin and DNA Methylation Changes of the Human Myeloperoxidase Gene During Myeloid Differentiation

          • M. Lübbert, C. W. Miller, R. Mertelsmann, F. Herrmann, H. P. Koeffler

          Pages 91-101

      11. Retroviral-Mediated Transfer of Genes Encoding for Growth Factors into Human Hematopoietic Stem Cells

          • A. A. Fauser, P. Laneuville, R. Tellier, G. Egert, G. W. Löhr

          Pages 103-106

   3. Colony Stimulating Factors in Malignant Hematopoiesis

      1. Recruitment Therapy in Acute Myeloblastic Leukemia:A Different Approach to Improved Leukemia Treatment

         • A. Tafuri, M. Andreeff

         Pages 107-113

      2. Effects of Hematopoietic Growth Factors on Myelodysplastic Syndrome Progenitors

         • X. Thomas, L. Campos, L. Vila, Z. H. Shi, D. Guyotat, D. Fiere

         Pages 115-122

      3. Combined Cytogenetic and Proliferation Studies of GM-CSF-Stimulated Bone Marrow Cells in Myelodysplasia and Acute Leukemia

         • D. Haase, C. Fonatsch

         Pages 123-128

The clinical and experimental effects of cytokines have been realized for a long time. The clinical effects of tumor necrosis factor were noted almost 100 years ago. The basic biological effects of interferons and the hemopoietic growth factors have been known for more than 20 years. Given the basis of modern molecular biotechniques, information concern­ ing the mediators of cellular interactions is expanding almost exponentially. New principles in the regulation of cell growth, microenvironment, immune response, and malignancy are being discoverd right now. New therapeutic options are becoming available and have, in some areas, already crossed the threshold of clinical application. However, the way forward might be more complicated than we are in a position to recognize today. Some of the first optimistic expectations have not yet been fulfilled. Nevertheless, we are experiencing a revolution in medicine. To contribute to this process and to stimulate scientific communi­ in this field, we have initiated the international symposia on cytokines cation in hemopoiesis, oncology and aids. Major contributions from the first sym­ posium are published in this book. We thank all the authors for their contri­ butions, particularly those from the Hannover Medical School, who have worked hard to realize the congress and prepare these proceedings. We also thank the pharmaceutical companies whose support made this book possible. Finally we thank Professors Deicher, Poliwoda, and Riehm, heads of the Departments of Hematology and Oncology, Immunology, and Pediatric Hematology and Oncology, respectively, who encouraged us and gave us their firm support.

• AIDS
• Carcinom
• Cytokine
• Hemopoietic Growth Factor
• Interferon
• Interleukin 2
• TNF
• Tumor-Nekrose-Faktor

• Abt. Hämatologie und Onkologie, Medizinische Hochschule Hannover, Hannover 61, Germany

  Mathias Freund, Hartmut Link

• Abt. Pädiatrische Hämatologie und Onkologie, Medizinische Hochschule Hannover, Hannover 61, Germany

  Karl Welte

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