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Interleukin-2-Induced Lymphokine-Activated Killer (LAK) Cells Against Human Leukemia: Improvement of Cytotoxicity by Combinations of Lymphokines or Cytokines

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Cytokines in Hemopoiesis, Oncology, and AIDS

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Abstract

It is now widely accepted that adoptive transferred LAK cells plus interleukin-2 (IL-2) or induction of cytotoxic mechanisms by IL-2 alone may play an important role in cancer therapy [1–11]. Most of the available data comes from experimental and clinical studies of solid tumors, while only little is known about the effect of LAK cells against human leukemia [12–14]. Leukemia patients have been reported to show a deficiency in natural killer (NK) cell functions which may contribute to leukemogenesis. The possibility of correcting this deficiency by IL-2 may be of great value in the treatment of human leukemia [15, 16]. Our study aimed at investigating the ability of LAK cells to lyse fresh human leukemia cells in vitro and improving the efficacy of cytotoxic mechanisms by combined application of IL-2 and other lymphokines or cytokines.

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Authors
  1. J. V. Teichmann
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  2. W.-D. Ludwig
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  3. E. Adler
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  4. E. Thiel
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Editors and Affiliations

  1. Abt. Hämatologie und Onkologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, D-3000, Hannover 61, Germany

    Mathias Freund  & Hartmut Link  & 

  2. Abt. Pädiatrische Hämatologie und Onkologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, D-3000, Hannover 61, Germany

    Karl Welte

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© 1990 Springer-Verlag, Berlin Heidelberg

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Teichmann, J.V., Ludwig, WD., Adler, E., Thiel, E. (1990). Interleukin-2-Induced Lymphokine-Activated Killer (LAK) Cells Against Human Leukemia: Improvement of Cytotoxicity by Combinations of Lymphokines or Cytokines. In: Freund, M., Link, H., Welte, K. (eds) Cytokines in Hemopoiesis, Oncology, and AIDS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75510-1_36

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  • DOI: https://doi.org/10.1007/978-3-642-75510-1_36

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52281-2

  • Online ISBN: 978-3-642-75510-1

  • eBook Packages: Springer Book Archive

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