Skip to main content
SpringerLink
Log in

Target Cell Specificity of Hematopoietic Growth Factors

  • Conference paper
Cytokines in Hemopoiesis, Oncology, and AIDS

Abstract

Over the past years our understanding of the regulation of the proliferation and differentiation of hematopoietic cells has greatly increased. The discovery of cytokines, a family of glycoproteins critically involved in various stages of hematopoiesis, has generated considerable enthusiasm about their potential usefulness as therapeutics. Since patients with hematologic and non hematologic neoplasms comprise a large population potentially benefitting from the clinical use of cytokines, the question of their target cell specificity needs to be addressed.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Sato K Mimura H, Han DC, Kakiuchi T, Ueyama Y, Onkawa H, Okabe T, Kondo Y, Ohsawa N, Tsushima T, et al. (1986) Production of bone-resorbing activity and colony-stimulating activity in vivo and in vitro by a human squamous cell carcinoma associated with hypercalcemia and leukocytosis. J Clin Invest 78:145–154

    Article  PubMed  CAS  Google Scholar 

  2. Murdoch FE, Shieh JH, Wu MC (1985) Differentiation factor distinct from colony-stimulating factor produced by human MIA-PACA-2 cells. Fed Proc 44:1099

    Google Scholar 

  3. Kondo Y, Sato K, Ohkawa H, Ueyama Y, Okabe T, Sato N, Asano S, Mori M, Ohsawa N, Kosaka K (1983) Association of hypercalcemia with tumors producing colony-stimulating factor(s). Cancer Res 43:2368–2374

    PubMed  CAS  Google Scholar 

  4. Takoaka K, Inoue S, Fujiya S, Kishi F, Abe S, Kawakami Y, Kobayashi M, Ishikawa N, Kikuchi Y, (1986) Report on a case producing colony-stimulating factor from anaplastic carcinoma of the thyroid. Nippon Naika Gakkai Zasshi 75:69–74

    Article  Google Scholar 

  5. Ikeda K, Motoyoshi K, Ishizaka Y, Hatake K, Kajigaya S, Saito M Miura Y, (1985) Human colony-stimulating activity-producing tumor:Production of very low mouse-active colony-stimulating activity and induction of marked granulocytosis in mice. Cancer Res 45:4144–4149

    PubMed  CAS  Google Scholar 

  6. Burrichter H, Heit W, Schaadt M, Kirchner H, Diehl V (1983) Production of colony-stimulating factors by Hodgkin cell lines. Int J Cancer 31:269–274

    Article  PubMed  CAS  Google Scholar 

  7. Moore W M, Wester W N, Spilburg C A (1986) Production of interleukin 1 by SK hepatoma tumor cells. Biochemistry 25:7696–7701

    Article  PubMed  CAS  Google Scholar 

  8. Bennicelli J, Elias J, Kern J Guerry D (1987) Metastatic melanoma cells secrete an interleukin-1 like activity. Proc Am Assoc Cancer Res 28:340

    Google Scholar 

  9. Fontana A, Hengartner H, de Tribolet N, Weber E (1984) Glioblastoma cells release interleukin 1 and factors inhibiting interleukin 2-mediated effects. J Immunol 132:1837–1844

    PubMed  CAS  Google Scholar 

  10. Sato K, Fujii Y, Ono M, Nomura H, Shizume K (1987) Production of interleukin 1 alpha-like factor and colony-stimulating factor by a squamous cell carcinoma of the thyroid (T3m-5) derived from a patient with hypercalcemia and leukocytosis. Cancer Res 47:6474–6480

    PubMed  CAS  Google Scholar 

  11. Ross HJ, Koeffler HP (1988) mRNAs coding for colony stimulating factors in transformed cells have increased stability. Blood [Suppl 1] 72:132a

    Google Scholar 

  12. Yee C, Biondi A, Huang XH, Iscove NN, De Sousa J, Aarden LA, Wong CG, Messner H, Minden MD (1988) A possible autocrine role for IL-6 in two lymphoma cell lines. Blood [Suppl 1] 72:139a

    Google Scholar 

  13. Hocking W, Goodman J, Golde D, (1983) Granulocytosis associated with tumor cell production of colony-stimulating activity. Blood 61:600–603

    PubMed  CAS  Google Scholar 

  14. Egami H, Sakamoto K, Yoshimura R, Kikuchi H, Akagi M (1986) Establishment of a cell line of gallbladder carcinoma (GBK-1) producing human colony stimulating factor. Jpn J Cancer Res 77:168–176

    PubMed  CAS  Google Scholar 

  15. Sakamoto K, Egami H, Yoshimura R, Nakamura S, Ikei S, Mori K, Matsumoto M, Akagi M (1986) Colony-stimulating factor producing carcinoma of the gallbladder. Jpn J Clin Oncol 16:87–96

    PubMed  CAS  Google Scholar 

  16. Pfluger KH, Probeck HD, Adler G, Stach-Machado D, Kapmeyer H, Havemann K (1986) Karyotype and ultrastructure of a colony stimulating factor (CSF) producing cell line (5637) originated from a carcinoma of the human urinary bladder. Blut 53, 89–100

    Article  PubMed  CAS  Google Scholar 

  17. Platzer E, Welte K, Lu L, Gabrilove J, Mertelsmann R, Moore MA (1984) Purification and biological characterization of human pluripotent colony-stimulating factor. Exp Hematol 12:415

    Google Scholar 

  18. Welte K, Platzer E, Lu L, Gabrilove JL, Levi E, Mertelsmann R, Moore MA (1985) Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor. Proc Natl Acad Sci USA 82:1526–1530

    Article  PubMed  CAS  Google Scholar 

  19. Tweardy DJ, Canizzaro LA, Palumbo AP, Shane S, Huebner K, Vantuinen P, Ledbetter DH, Finan JB, Nowell PC, Rovera G (1987) Molecular cloning and characterization of an cDNA for human granulocyte colony-stimulating-factor (G-CSF) gene to chromosome band 17q21. Oncogene Res 1:209–220

    PubMed  CAS  Google Scholar 

  20. Shieh JH, Cini JK, Wu M C, Yunis A A (1987) Purification and characterization of human colony-stimulating factor 1 from human pancreatic carcinoma (MIA PACA-2) cells. Arch Biochem Biophys 253:205–213

    Article  PubMed  CAS  Google Scholar 

  21. Csejtey J, Boosman A (1986) Purification of human macrophage colony stimulating factor (CSF-1) from medium conditioned by pancreatic carcinoma cells. Biochem Biophys Res Commun 138:238–245

    Article  PubMed  CAS  Google Scholar 

  22. Montag TW, Murphy RE, Belinson JL (1984) Virilizing malignant lipid cell tumor producing erythropoietin. Gynecol Oncol 19:98–103

    Article  PubMed  CAS  Google Scholar 

  23. Nagakura K, Brookins J, Fisher JW (1986) Low levels of calcium increase erythropoietin (EP) secretion by human renal carcinoma cells in culture. Fed Proc 45:655

    Google Scholar 

  24. Sherwood JB, Burns ER, Shouval D (1987) Stimulation by champ of erythropoietin secretion by an established human renal carcinoma cell line. Blood 69:1053–1057

    PubMed  CAS  Google Scholar 

  25. Sytkowski AJ, Bicknell KA, Smith GM, Garcia JF (1984) Secretion of erythropoietin-like activity by clones of human renal carcinoma cell line GKA. Cancer Res 44:51–54

    PubMed  CAS  Google Scholar 

  26. Sytkowski AJ, Richie JP, Bicknell KA (1983) New human renal carcinoma cell line established from a patient with erythrocytosis. Cancer Res 43:1415–1419

    PubMed  CAS  Google Scholar 

  27. Sytkowsky AJ, Bicknell KA (1981) Erythropoietin secretion by continuous cell lines of human renal carcinoma. Clin Res 29:350A

    Google Scholar 

  28. Hirata J, Koga T, Nishimura J, Ibayashi H (1987) Pancreatic carcinoma associated with marked eosinophilia:case report. Eur J Haematol 39:462–466

    Article  PubMed  CAS  Google Scholar 

  29. Kishi K, Hirosawa H, Fujiwara M, Moriyama Y, Shinada S, Okazaki E, Tsukada T, Shibata A (1984) Colony stimulating factor producing tumor cell line derived from a patient with renal rhabdomyosarcoma. Rinsho Ketsueki 25:1618–1625

    PubMed  CAS  Google Scholar 

  30. Nishimura M, Itoh K, Tsuda K, Osegawa M, Wong PM (1986) CSF (colony stimulating factor)-producing renal cell carcinoma:a case report. Rinsho Ketsueki 27:2131–2135

    PubMed  CAS  Google Scholar 

  31. Takahashi M, Fujiwara M, Kishi K, Sakai C, Sanada M, Moriyama Y, Hattori A, Shibata A, Nishimaki T, Hirota M, et al (1983) CSF-producing gall bladder neoplasm. Presentation of a case and characteristics of CSF produced by tumor cells. Nippon Ketsueki Gakkai Zasshi 46:1037–1044

    PubMed  CAS  Google Scholar 

  32. Ichinose Y, Yagawa K, Kaku M, Tanaka K, Hara N, Yamano Y, Niho Y, Ohta M (1985) Superoxide anion generation by polymorphonuclear leukocytes enhanced in a patient with colony-stimulating activity-producing lung cancer. Eur J Cancer Clin Oncol 21:181–184

    Article  PubMed  CAS  Google Scholar 

  33. Kikuchi H (1985) Studies on the granulocyte and/or macrophage colony-stimulating factor (CSF) in the urine and a medium conditioned in vitro by tumor cells from a patient with CSF-producing lung cancer. Igaku Kenkyu 55:242–279

    PubMed  CAS  Google Scholar 

  34. Mizoguchi H, Suda T, Miura Y, Kubota K, Takaku F (1982) Hemopoietic stem cells in nude mice transplanted with colony-stimulating-factor-producing tumors. Exp Hematol 10:874–880

    PubMed  CAS  Google Scholar 

  35. O’Brien HA, Horton MA (1984) High colony stimulating activity in a patient with disseminated carcinoma and neutrophil leucocytosis. J Clin Pathol 37:665–668

    Article  PubMed  Google Scholar 

  36. Yamada T, Hirobashi S, Shimosato Y, Kodama T, Hayashi S, Ogura T, Gamou S, Shimizu N (1985) Giant cell carcinomas of the lung producing colony-stimulating factor in vitro and in vivo. Jpn J Cancer Res 76:967–976

    PubMed  CAS  Google Scholar 

  37. Nara N, Hirashima K (1983) Relationship between marked leukocytosis and urinary colony-stimulating activity (CSA) in a patient with carcinoma of the uterine cervix. Nippon Ketsueki Gakkai Zasshi 46:114–120

    PubMed  CAS  Google Scholar 

  38. Obara T, Ito Y, Kodama T, Fujimoto Y, Mizoguchi H, Oshimi K, Takahashi M, Hirayama A (1985) A case of gastric carcinoma associated with excessive granulocytosis. Production of a colony-stimulating factor by the tumor. Cancer 56:782–788

    Article  PubMed  CAS  Google Scholar 

  39. Takeda A, Suzumori K, Sugimoto V, Yagami Y, Miyazawa T, Yamada C, Matsuyama M (1984) Clear cell carcinoma of the ovary with colony-stimulating-factor production. Occurrence of marked granulocytosis in a patient and nude mice. Cancer 54:1019–1023

    Google Scholar 

  40. Mano H, Nishida J, Usuki K, Maru Y, Kobayashi Y, Hirai H, Okabe T, Urabe A, Takaku F (1987) Constitutive expression of the granulocyte-macrophage colony-stimulating factor gene in human solid tumors. Jpn J Cancer Res 78:1041–1043

    PubMed  CAS  Google Scholar 

  41. Asano S, Sato N, Mori M, Ohsawa N, Kosaka K, Ueyama Y (1980) Detection and assessment of human tumors producing granulocyte-macrophage colony-stimulating factor ( GM-CSF) by heterotransplantation into nude mice. Br J Cancer 41:689–694

    Google Scholar 

  42. Nielsen OJ, Jespersen FF, Hilden M (1988) Erythropoietin-induced secondary polycythemia in a patient with a renal cell carcinoma:a case report APMIS 96:688–694

    CAS  Google Scholar 

  43. Saint-Jean O, Boffa GA, Bouchon JP, Verret J (1985) Polyglobulie secondaire avec hyper-erythropoietinemie. Meningiome sus-tentoriel. (Secondary polycythemia with hypererythropoietinemia. Supratentorial meningioma ). Rev Neurol (Paris) 141:143–145

    Google Scholar 

  44. Gaffney EV, Koch G, Tsai SC, Loucks T, Lingenfelter SE (1988) Correlation between human cell growth response to interleukin 1 and receptor binding. Cancer Res 48:5455–5459

    PubMed  CAS  Google Scholar 

  45. Horuk R, Huang JJ, Covington M, Newton RC (1987) A biochemical and kinetic analysis of the interleukin-1 receptor. Evidence for differences in molecular properties of IL-1 receptors. J Biol Chem 262:16275–16278

    PubMed  CAS  Google Scholar 

  46. Hamburger AW, Lurie KA, Condon ME (1987) Stimulation of anchorage-independent growth of human tumor cells by interleukin 1. Cancer Res 47:5612–5615

    PubMed  CAS  Google Scholar 

  47. Duprez V, Cornet V, Dautry-Varsat A (1988) Down-regulation of high affinity interleukin 2 receptors in a human tumor T cell line. Interleukin 2 increases the rate of surface receptor decay. J Biol Chem 263:12860–12865

    PubMed  CAS  Google Scholar 

  48. Baldwin GC, DiPersio J, Kaufman SE, Quan SG, Golde DW, Gasson JC (1987) Characterization of human GM-CSF receptors on non-hematopoietic cells. Blood [Suppl 1] 70:166

    Google Scholar 

  49. Berdel WE, Dannhauser-Riedl S, Steinhauser G, Winton EF (1989) Various human hematopoietic growth factors (Interleukin-3, GM-CSF, G-CSF) stimulate clonal growth of nonhematopoietic tumor cells. Blood 73:80–83

    Google Scholar 

  50. Nachbaur D, Denz H, Zwierzina H, Huber H (1989) Stimulation of colony formation of various human carcinoma cell lines by rhGM-CSF and rhIL-3. Cytokines in hemopoiesis, oncology and AIDS, First International Symposium, 14–17 June 1989

    Google Scholar 

  51. Dedhar S, Gaboury L, Galloway P, Eaves C (1988) Human granulocyte-macrophage colony-stimulating factor is a growth factor active on a variety of cell types of nonhematopoietic origin. Proc Natl Acad Sci USA 85:9253–9257

    Article  PubMed  CAS  Google Scholar 

  52. Herman J, Rabson AR (1986) Tumor cells stimulate interleukin 1 (IL-1) production from enriched large granular lymphocytes. Clin Immunol Immunopathol 38:282–294

    Article  PubMed  CAS  Google Scholar 

  53. Hamburger AW, Salmon SE (1977) Primary bioassay of human tumor stem cells. Science 197:461–463

    Article  PubMed  CAS  Google Scholar 

  54. Dower SK, Call SM, Gillis S, Urdal DL (1986) Similarity between the interleukin 1 receptors on a murine T-lymphoma cell line and on a murine fibroblast cell line. Proc Natl Acad Sci USA 83:1060–1064

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. A.-R. Hanauske
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abt. Hämatologie und Onkologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, D-3000, Hannover 61, Germany

    Mathias Freund  & Hartmut Link  & 

  2. Abt. Pädiatrische Hämatologie und Onkologie, Medizinische Hochschule Hannover, Konstanty-Gutschow-Straße 8, D-3000, Hannover 61, Germany

    Karl Welte

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag, Berlin Heidelberg

About this paper

Cite this paper

Hanauske, AR. (1990). Target Cell Specificity of Hematopoietic Growth Factors. In: Freund, M., Link, H., Welte, K. (eds) Cytokines in Hemopoiesis, Oncology, and AIDS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75510-1_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-75510-1_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52281-2

  • Online ISBN: 978-3-642-75510-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation