Several Cytokines Do not Influence Activity of P210BCR-ABL Kinase in K562 Cells

  • A. Käbisch
  • T. Tamura
  • H. Pralle
Conference paper

Abstract

Chronic myelogenous leukemia (CML) is a disease which has, in its chronic phase, the dominant feature of a myeloproliferative disorder. It is characterized by the clonal expansion of a hematopoietic stem cell.

Keywords

EDTA Tyrosine Leukemia Electrophoresis Polypeptide 

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References

  1. 1.
    Alitalo R (1987) The bcr-c-abl tyrosine kinase activity is extinguished by TPA in K562 leukemia cells. FEBS Lett 222:293–298PubMedCrossRefGoogle Scholar
  2. 2.
    Fraser JK, Lin F-K, Berridge MV (1988) Expression and modulation of specific high affinity binding sites for erythropoietin on the human erythroleukemia cell line K562. Blood 71:104–109PubMedGoogle Scholar
  3. 3.
    Ganser A. Völkers B, Scigalla P, Hoelzer D (1988) Effect of human recombinant erythropoietin on human hemopoietic progenitor cells in-vitro. Klin Wochenschr 66:236–240PubMedCrossRefGoogle Scholar
  4. 4.
    Harel-Bellan P, Farrar WC (1987) Modulation of protooncogene expression by colony stimulating factors. Biochem Biophys Res Commun 148:1001–1008PubMedCrossRefGoogle Scholar
  5. 5.
    Herrmann F, Mertelsmann R (1989) Polypeptides controlling hematopoietic cell development and activation. I. In vitro results. Blut 58:117–128Google Scholar
  6. 6.
    Lopez AF, TO LB, Yang Y-C et al. (1987) Stimulation of proliferation, differentiation, and function of human cells by primate interleukin-3. Proc Natl Acad Sci USA 84:2761–2765PubMedCrossRefGoogle Scholar
  7. 7.
    Lozzio CB, Lozzio BB (1975) Human chronic myelogenous cell line with positive Philadelphia-chromosome. Blood 45:321PubMedGoogle Scholar
  8. 8.
    Muncker R, DiPerio J, Koeffler HP (1987) Tumor necrosis factor:receptors on hematopoietic cells. Blood 70:1730–1734Google Scholar
  9. 9.
    Nishimura J, Takahira H, Shibata K et al. (1988) Regulation of biosynthesis and phosphorylation of P210bcr-abl protein during differentiation induction of K562 cells. Leuk Res 12:875–885PubMedCrossRefGoogle Scholar
  10. 10.
    Sieff CA, Tsai S, Faller DV (1987) Interleukin-1 induces cultured human endothelial cell production of granulocyte-macrophage colony stimulating factor. J Clin Invest 79:48–51PubMedCrossRefGoogle Scholar
  11. 11.
    Sieff CA (1987) Hematopoietic growth factors. J Clin Invest 79:1549–1557PubMedCrossRefGoogle Scholar
  12. 12.
    Young JC, Witte ON (1988) Selective transformation of primitive lymphoid cells by the BCR-ABL oncogene expressed in long term lymphoid or myeloid cultures. Mol Cell Biol 8:4049–4057Google Scholar
  13. 13.
    Laemmli, UK (1970), Cleavage of structurae proteins during the assembly of the head of bacteriophage T4 Nature 227, 680–685PubMedCrossRefGoogle Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1990

Authors and Affiliations

  • A. Käbisch
  • T. Tamura
  • H. Pralle

There are no affiliations available

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