Advertisement

Fibroblast Colony Stimulating Activity of GM-CSF and IL-3 in Human Bone Marrow Cell Cultures

  • P. Valent
  • K. Geissler
  • P. Kalhs
  • P. Kier
  • P. Bettelheim
Conference paper

Abstract

Bone marrow stroma cells are supposed to represent a significant cell population in the hemopoietic microenvironment. They have been shown to form colonies and to arise from their specific clonogenic precursors (stroma cell colony forming units, CFU ST) in appropriate culture systems [1–3].

Keywords

Human Bone Marrow Bone Marrow Precursor Bone Marrow Cell Culture Immunological Phenotype Culture Bone Marrow Stroma Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    Castro-Malaspina H, Gay RE, Resnick G, Kapoor N, Meyers P, Chiarieri D, Mckenzie S, Broxmeyer HE, Moore As (1980) Characterization of human bone marrow fibroblast colony forming cells ( CFU-F) and their progeny. Blood 56:289–301PubMedGoogle Scholar
  2. 2.
    Kaneku S, Motomura S, Ibayashi H (1982) Differentiation of human bone marrow derived fibroblast colony forming cells ( CFU-F) and their role in hemopoiesis in vitro. Br J Haematol 51:217–225Google Scholar
  3. 3.
    Dedhar S, Gaboury L, Galloway P, Eaves C (1988) Human granulocyte macrophage colony- stimulating factor is a growth factor active on a variety of cells of non hemopoietic origin. Proc Natl Acad Sci USA 85:9253–9257PubMedCrossRefGoogle Scholar
  4. 4.
    Mclntyre AP, Bjornson BH (1988) Human bone marrow stromal cell colonies:response to hydrocortisone and dependence on platelet derived growth factor. Exp Hematol 14:833–839Google Scholar
  5. 5.
    Clark SC, Kamen R (1988) The human hematopoietic colony-stimulating factors. Science 229:16–22Google Scholar
  6. 6.
    Bot JF, Dorrsers L, Wagemaker G, Lowenberg B (1988) Stimulating spectrum of human recombinant multi-CSF (IL-3) on human marrow precursors:Importance of accessory cells. Blood 71:1609–1614PubMedGoogle Scholar
  7. 7.
    Valent P, Schmidt G, Besemer J, Mayer P, Zenke G, Liehl E, Hinterberger W, Lechner K, Maurer D, Bettelheim P (1989) Interleukin 3 is a differentiation factor for human basophils. Blood 73:1763–1768PubMedGoogle Scholar
  8. 8.
    Mayer P, Valent P, Schmidt G, Liehl E, Bettelheim P (1989) The in vivo effects of recombinant human IL-3:demonstration of basophil differentiation factor, histamine producing activity and primary of GM-CSF responsive progenitors in non human primates. Blood 74:613–621PubMedGoogle Scholar
  9. 9.
    Berdel WE, Danhauser-Riedl S, Steinhauser G, Winton EF (1989) Various human hematopoietic growth factors (Interleukin-3, GM-CSF, G-CSF) stimulate clonal growth of non- hematopoietic tumor cells. Blood 73:80–83PubMedGoogle Scholar

Copyright information

© Springer-Verlag, Berlin Heidelberg 1990

Authors and Affiliations

  • P. Valent
  • K. Geissler
  • P. Kalhs
  • P. Kier
  • P. Bettelheim

There are no affiliations available

Personalised recommendations