Skip to main content

Fibroblast Colony Stimulating Activity of GM-CSF and IL-3 in Human Bone Marrow Cell Cultures

  • Conference paper
Cytokines in Hemopoiesis, Oncology, and AIDS
  • 72 Accesses

Abstract

Bone marrow stroma cells are supposed to represent a significant cell population in the hemopoietic microenvironment. They have been shown to form colonies and to arise from their specific clonogenic precursors (stroma cell colony forming units, CFU ST) in appropriate culture systems [1–3].

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Castro-Malaspina H, Gay RE, Resnick G, Kapoor N, Meyers P, Chiarieri D, Mckenzie S, Broxmeyer HE, Moore As (1980) Characterization of human bone marrow fibroblast colony forming cells ( CFU-F) and their progeny. Blood 56:289–301

    PubMed  CAS  Google Scholar 

  2. Kaneku S, Motomura S, Ibayashi H (1982) Differentiation of human bone marrow derived fibroblast colony forming cells ( CFU-F) and their role in hemopoiesis in vitro. Br J Haematol 51:217–225

    Google Scholar 

  3. Dedhar S, Gaboury L, Galloway P, Eaves C (1988) Human granulocyte macrophage colony- stimulating factor is a growth factor active on a variety of cells of non hemopoietic origin. Proc Natl Acad Sci USA 85:9253–9257

    Article  PubMed  CAS  Google Scholar 

  4. Mclntyre AP, Bjornson BH (1988) Human bone marrow stromal cell colonies:response to hydrocortisone and dependence on platelet derived growth factor. Exp Hematol 14:833–839

    Google Scholar 

  5. Clark SC, Kamen R (1988) The human hematopoietic colony-stimulating factors. Science 229:16–22

    Google Scholar 

  6. Bot JF, Dorrsers L, Wagemaker G, Lowenberg B (1988) Stimulating spectrum of human recombinant multi-CSF (IL-3) on human marrow precursors:Importance of accessory cells. Blood 71:1609–1614

    PubMed  CAS  Google Scholar 

  7. Valent P, Schmidt G, Besemer J, Mayer P, Zenke G, Liehl E, Hinterberger W, Lechner K, Maurer D, Bettelheim P (1989) Interleukin 3 is a differentiation factor for human basophils. Blood 73:1763–1768

    PubMed  CAS  Google Scholar 

  8. Mayer P, Valent P, Schmidt G, Liehl E, Bettelheim P (1989) The in vivo effects of recombinant human IL-3:demonstration of basophil differentiation factor, histamine producing activity and primary of GM-CSF responsive progenitors in non human primates. Blood 74:613–621

    PubMed  CAS  Google Scholar 

  9. Berdel WE, Danhauser-Riedl S, Steinhauser G, Winton EF (1989) Various human hematopoietic growth factors (Interleukin-3, GM-CSF, G-CSF) stimulate clonal growth of non- hematopoietic tumor cells. Blood 73:80–83

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1990 Springer-Verlag, Berlin Heidelberg

About this paper

Cite this paper

Valent, P., Geissler, K., Kalhs, P., Kier, P., Bettelheim, P. (1990). Fibroblast Colony Stimulating Activity of GM-CSF and IL-3 in Human Bone Marrow Cell Cultures. In: Freund, M., Link, H., Welte, K. (eds) Cytokines in Hemopoiesis, Oncology, and AIDS. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75510-1_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-75510-1_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-52281-2

  • Online ISBN: 978-3-642-75510-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics