Abstract
The ability to respond to external stimulation is a fundamental property of all cells. The characteristics of the surrounding extracellular matrix (ECM) are critical to the regulation of the phenotype of the cell, which in turn is intimately associated with the particular function(s) of the cell. Changes in the chemical and physical composition of the ECM can cause altered cellular function as evidenced during the development of an organism or in progression of various disease conditions. Changes in the composition of the ECM as well as the development of mechanical force are known factors affecting embryonic and fetal development of the heart [1–3]. These changes may also be recapitulated during certain disease conditions such as cardiac hypertrophy [1, 3].
The research described was supported in part by NIH grants HL-24935, HL-42249, HL-404424, and HL-37669.
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Borg, T.K., Terracio, L. (1990). Attachment Substrates for Heart Muscle Cells. In: Piper, H.M. (eds) Cell Culture Techniques in Heart and Vessel Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75262-9_6
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DOI: https://doi.org/10.1007/978-3-642-75262-9_6
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