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Growth Factors for Vascular Endothelial Cells

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Cell Culture Techniques in Heart and Vessel Research

Abstract

The search for the molecular mediators of growth control in vascular endothelial cells has led to the discovery of a family of endothelial cell growth factors (ECGFs) which differ widely in their ability to trigger endothelial cell proliferation and differentiation in an in vitro or in vivo context. Among the first vascular ECGFs to be described was the basic Fibroblast growth factor (bFGF) isolated from the brain or pituitary [24, 33] and its closely related member, the acidic fibroblast factor (aFGF) [4, 58, 92]. At this date; at least nine ECGFs and angiogenic factors have been isolated and characterized (Table 1). Although all these factors have been shown to be angiogenic in vivo, they differ widely in their target cell specificity and by their ability to stimulate endothelial cell growth in vitro versus in vivo.

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  1. Physiologisches Institut, Abteilung für Herz- und Kreislaufphysiologie der Universität Düsseldorf, Moorenstr. 5, D-4000, Düsseldorf 1, Germany

    H. M. Piper

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Gospodarowicz, D. (1990). Growth Factors for Vascular Endothelial Cells. In: Piper, H.M. (eds) Cell Culture Techniques in Heart and Vessel Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75262-9_16

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  • DOI: https://doi.org/10.1007/978-3-642-75262-9_16

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