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Microvascular Endothelial Cells from Brain

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Cell Culture Techniques in Heart and Vessel Research

Abstract

In addition to providing a nonthrombogenic surface, synthesizing factor VIII, and participating in vascular tone regulation, most endothelial cells of the vasculature of the brain participate in the blood-brain barrier. The bloodbrain barrier severely restricts the entry of macromolecules into nervous tissue and provides a selective permeability barrier to a variety of other solutes [5, 23]. The site of this barrier is the brain endothelial cells which exhibit continuous tight junctions, very low amounts of transcytosis, and a polar distribution of transport carriers between luminal and antiluminal plasma membranes.

The opinons and assertions contained herein are the private views of the authors and are not to be construed as official nor do they reflect the views of the Department of the Army or the Department of Defense (AR 360-5)

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Authors
  1. P. D. Bowman
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  2. M. du Bois
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  3. K. Dorovini-Zis
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  4. R. R. Shivers
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Editors and Affiliations

  1. Physiologisches Institut, Abteilung für Herz- und Kreislaufphysiologie der Universität Düsseldorf, Moorenstr. 5, D-4000, Düsseldorf 1, Germany

    H. M. Piper

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Bowman, P.D., du Bois, M., Dorovini-Zis, K., Shivers, R.R. (1990). Microvascular Endothelial Cells from Brain. In: Piper, H.M. (eds) Cell Culture Techniques in Heart and Vessel Research. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75262-9_10

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  • DOI: https://doi.org/10.1007/978-3-642-75262-9_10

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