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Single-Strand Breaks and Base Damage in DNA of Human White Blood Cells in Full Blood Exposed to Ionizing Radiation Detected at Biologically Relevant Doses

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The Early Effects of Radiation on DNA

Part of the book series: NATO ASI Series ((ASIH,volume 54))

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Abstract

Both physical (UV- and X-irradiation) and chemical agents can damage cells. Of special interest are the DNA molecules, the carriers of the genetic information. Damage inflicted on DNA, unless repaired, may kill cells by interference with transcription and replication or by the induction of mutations. Non-lethal mutations may result in cells with altered properties which may contribute to ageing, heart diseases and cancer.

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Reference

  • Van der Schans GP, Van Loon AAWM, Groenendijk RH, Baan RA (1989) Int J Radiat Biol 55: 747–760

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  • Van Loon AAWM, Groenendijk RH, Van der Schans GP, Lohman PHM, Baan RA (1990) (submitted to Int J Radiat Biol)

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Authors and Affiliations

  1. TNO Medical Biological Laboratory, Lange Kleiweg 139, 2288, GJ Rijswijk, The Netherlands

    A. A. W. M. van Loon, G. P. van der Schans, A. J. Timmerman, F. J. A. Kouwenberg, R. H. Groenendijk, P. H. M. Lohman & R. A. Baan

  2. Laboratory for Radiation Genetics and Chemical Mutagenesis, Sylvius Laboratory, State University of Leiden, Netherlands

    A. A. W. M. van Loon & P. H. M. Lohman

Authors
  1. A. A. W. M. van Loon
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  2. G. P. van der Schans
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  3. A. J. Timmerman
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  4. F. J. A. Kouwenberg
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  5. R. H. Groenendijk
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  6. P. H. M. Lohman
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  7. R. A. Baan
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Editor information

Editors and Affiliations

  1. Medical Research Council, Radiobiology Unit, Chilton, Didcot, Oxon, OX11 ORD, UK

    E. M. Fielden  & P. O’Neill  & 

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© 1991 Springer-Verlag Berlin Heidelberg

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van Loon, A.A.W.M. et al. (1991). Single-Strand Breaks and Base Damage in DNA of Human White Blood Cells in Full Blood Exposed to Ionizing Radiation Detected at Biologically Relevant Doses. In: Fielden, E.M., O’Neill, P. (eds) The Early Effects of Radiation on DNA. NATO ASI Series, vol 54. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75148-6_10

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  • DOI: https://doi.org/10.1007/978-3-642-75148-6_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-75150-9

  • Online ISBN: 978-3-642-75148-6

  • eBook Packages: Springer Book Archive

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