Single-Strand Breaks and Base Damage in DNA of Human White Blood Cells in Full Blood Exposed to Ionizing Radiation Detected at Biologically Relevant Doses

  • A. A. W. M. van Loon
  • G. P. van der Schans
  • A. J. Timmerman
  • F. J. A. Kouwenberg
  • R. H. Groenendijk
  • P. H. M. Lohman
  • R. A. Baan
Conference paper
Part of the NATO ASI Series book series (volume 54)

Abstract

Both physical (UV- and X-irradiation) and chemical agents can damage cells. Of special interest are the DNA molecules, the carriers of the genetic information. Damage inflicted on DNA, unless repaired, may kill cells by interference with transcription and replication or by the induction of mutations. Non-lethal mutations may result in cells with altered properties which may contribute to ageing, heart diseases and cancer.

Keywords

Leukemia Endoxan 

Reference

  1. Van der Schans GP, Van Loon AAWM, Groenendijk RH, Baan RA (1989) Int J Radiat Biol 55: 747–760PubMedCrossRefGoogle Scholar
  2. Van Loon AAWM, Groenendijk RH, Van der Schans GP, Lohman PHM, Baan RA (1990) (submitted to Int J Radiat Biol)Google Scholar

Copyright information

© Springer-Verlag Berlin Heidelberg 1991

Authors and Affiliations

  • A. A. W. M. van Loon
    • 1
    • 2
  • G. P. van der Schans
    • 1
  • A. J. Timmerman
    • 1
  • F. J. A. Kouwenberg
    • 1
  • R. H. Groenendijk
    • 1
  • P. H. M. Lohman
    • 1
    • 2
  • R. A. Baan
    • 1
  1. 1.TNO Medical Biological LaboratoryGJ RijswijkThe Netherlands
  2. 2.Laboratory for Radiation Genetics and Chemical Mutagenesis, Sylvius LaboratoryState University of LeidenNetherlands

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