Single-Strand Breaks and Base Damage in DNA of Human White Blood Cells in Full Blood Exposed to Ionizing Radiation Detected at Biologically Relevant Doses
Both physical (UV- and X-irradiation) and chemical agents can damage cells. Of special interest are the DNA molecules, the carriers of the genetic information. Damage inflicted on DNA, unless repaired, may kill cells by interference with transcription and replication or by the induction of mutations. Non-lethal mutations may result in cells with altered properties which may contribute to ageing, heart diseases and cancer.