The Early Effects of Radiation on DNA

  • E. M. Fielden
  • P. O’Neill

Part of the NATO ASI Series book series (volume 54)

Table of contents

  1. Front Matter
    Pages I-XII
  2. The Interdisciplinary Approach to Radiation Action

  3. Cellular DNA Strand Breakage

  4. Early Chemical Events in DNA Damage

  5. Development of Radiation Models

  6. Chemical Mechanisms of Dose Modifiers

  7. RBE from Theory to Experimental

    1. T. C. Akpa, K. J. Weber, J. Kiefer, M. Frankenberg-Schwager, R. Harbich, D. Frankenberg
      Pages 307-308
    2. M. Belli, D. T. Goodhead, F. Ianzini, T. J. Jenner, G. Simone, M. A. Tabocchini
      Pages 309-310
  8. Timescale for Development of DNA Damage

    1. D. Schulte-Frohlinde, E. Bothe
      Pages 317-332
    2. Barry D. Michael, Kevin M. Prise, Robert C. Fahey, Melvyn Folkard
      Pages 333-346
    3. John M. Warman
      Pages 365-368
  9. Let and Chromosomal Damage

  10. Additional Short Presentations

    1. J. Cadet, M. Berger, J. F. Mouret, F. Odin, M. Polverelli, J. L. Ravanat
      Pages 403-404
    2. A. F. Fuciarelli, W. F. Blakely, B. J. Wegher, M. Dizdaroglu
      Pages 405-408
  11. Workshop Summaries

    1. Dudley T. Goodhead
      Pages 413-416
    2. John F. Ward
      Pages 417-420

About these proceedings


Interest in the biological effects of ionising radiation closely followed the identification of such radiation. The realisation that DNA is the site of genetic infonnation in cells subsequently focussed attention on DNA as an important target in the lethal and mutagenic effects of ionising radiation. Thus radiation effects upon DNA became an important area for fundamental scientific studies by radiation biologists, chemists and physicists. To a first approximation, the concerns of the three disciplines can be divided by time scales: the physical process of energy deposition from photon or charged 16 12 particle and subsequent relaxation (-10- to 10- secs), followed by chemical 12 2 reactions (- 10- to 10 secs), and fmally, the expression of biological effect (minutes to years). Thus, the concept of 'early processes' conveys different ideas to different scientists, although they are all interrelated. To attempt to describe in any detail all these processes is a mammoth task which is not made easier by the different conventions and experimental approaches of the three disciplines. However, the recent advances in all these scientific areas seemed, to the organisers at least, to offer the opportunity to stimulate more active interaction between physicists, chemists and biologists. With this in mind, a multi-disciplinary workshop was organised, which brought together some fifty scientists to present their own specialist interests and, through extensive discussion, explore which problems are of high priority and require input from the different disciplines to resolve them.


Chromosom DNA Erbgut Mutation Radiation Strahlung

Editors and affiliations

  • E. M. Fielden
    • 1
  • P. O’Neill
    • 1
  1. 1.Medical Research CouncilRadiobiology UnitChilton, Didcot, OxonUK

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 1991
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-75150-9
  • Online ISBN 978-3-642-75148-6
  • Buy this book on publisher's site
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