Abstract
Graves’ disease, the major form of autoimmune thyroid disease, is believed to be caused by autoantibodies to the thyrotropin (TSH) receptor. How these antibodies develop is still unknown; it is also not clear whether this is a thyroid disease or one of abnormal lymphocyte control. It can be presumed that the TSH receptor is structurally related to the receptors for other glycoprotein hormones; yet its relatively unique role as an autoantigen is unexplained. Further, it is increasingly evident that the sera of patients with Graves’ disease have a multiplicity of antibodies to thyroid antigens in addition to the TSH receptor and that these may be relevant to understanding the expression of the disease or its pathogenesis.
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Kohn, L.D., Akamizu, T., Saji, M., Ikuyama, S., Bellur, S., Tahara, K. (1990). The Cloning Road to the TSH Receptor and Autoimmune Graves’ Disease. In: Demaine, A.G., Banga, JP., McGregor, A.M. (eds) The Molecular Biology of Autoimmune Disease. NATO ASI Series, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75133-2_35
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DOI: https://doi.org/10.1007/978-3-642-75133-2_35
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