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The Molecular Biology of Autoimmune Disease

  • Conference proceedings
  • © 1990

Overview

Editors:
  1. Andrew G. Demaine

    1. Department of Medicine, King’s College School of Medicine, London, UK

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  2. J-Paul Banga

    1. Department of Medicine, King’s College School of Medicine, London, UK

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    You can also search for this editor in PubMed   Google Scholar

  3. Alan M. McGregor

    1. Department of Medicine, King’s College School of Medicine, London, UK

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Part of the book series: Nato ASI Subseries H: (ASIH, volume 38)

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Table of contents (37 papers)

  1. Front Matter

    Pages I-XII
    Download chapter PDF

  2. Structure and Function of Immunoglobulins and Their Genes

    1. Organization and Expression of Human VH Genes

      • T. Logtenberg, J. E. Berman, F. W. Alt
      Pages 1-14

    2. Immunoglobulin Kappa Variable Gene Segment Usage during Ontogeny

      • A. Lawler, P. Gearhart
      Pages 15-22

  3. Structure and Function of the T Cell Receptor and Its Genes

    1. Molecular Analysis of T Lymphocyte Recognition

      • B. Malissen, D. Blanc, D. Couez, J. Gabert, C. Gregoire, I. Hue et al.
      Pages 23-29

    2. T Cell Development in T Cell Receptor Transgenic Mice

      • Horst Blüthmann, Michael Steinmetz, Harald von Boehmer
      Pages 31-44

    3. Target Sequences and Accessibility for Chromosomal Translocations Involving T-Cell Receptor Genes

      • T. H. Rabbitts, T. Boehm, A. Forster, I. Lavenir, L. Mengle-Gaw
      Pages 45-54

  4. Structure and Function of the MHC and Its Genes

    1. Introduction

      • H. A. Erlich
      Pages 55-59

    2. Structure of Human Major Histocompatibility Complex Class II Genes

      • Lars Rask, Ann-Kristin Jonsson, Stefan Lundgren, Leif Andersson
      Pages 61-69

    3. Dissection of the Roles of Specific Class II Antigens and Accessory Molecules in Antigen Presentation

      • Daniel M. Altmann, David Wilkinson, Hitoshi Ikeda, John Trowsdale
      Pages 71-83

    4. The Fine Specificity of Recognition of Influenza Virus Proteins by Human Cytotoxic T Cells

      • Frances M. Gotch
      Pages 85-96

    5. Chairman’s Summing up Evolutionary Analysis of HLA Class II Polymorphisms

      • H. A. Erlich
      Pages 97-107

  5. Auto-Antigen Characterisation

    1. Molecular Genetics of Two Major Thyroid Auto-Antigens: Thyroglobulin and Thyroperoxidase

      • M. Ludgate, G. Vassart
      Pages 109-120

    2. Analysis of Autoantigenic Determinants of Thyroid Peroxidase Antigen, Generated Using Polymerase Chain Reaction

      • J. Paul Banga, Philip S. Barnett, David L. Ewins, Martin J. Page, Alan M. McGregor
      Pages 121-134

    3. Glycolipid Antigens in Type I Diabetes Mellitus and Its Long Term Complications

      • Ramesh C. Nayak
      Pages 135-145

    4. On the Main Immunogenic Region of the Acetylcholine Receptor. Structure and Role in Myasthenia Gravis

      • S. J. Tzartos, D. Sophianos, A. Kordossi, I. Papadouli, I. Hadjidakis, C. Sakarellos et al.
      Pages 147-158

    5. Acetylcholine Receptor-Expressing Fibroblasts

      • Toni Claudio
      Pages 159-170

  6. Antigen Processing and Presentation

    1. The Interaction between MHC Class II Molecules and Immunogenic Peptides

      • S. Buus, A. Sette, E. B. Shaeffer, H. M. Grey
      Pages 171-179

    2. Molecular Mimicry between Virus Proteins and Autoantigens in Autoimmunity

      • Thomas Dyrberg
      Pages 181-191

  7. Interaction of Auto-Antigen, MHC and T Cell Receptor

    1. Introduction

      • C. A. Janeway
      Pages 193-198

    2. The Advantages of Limiting the T Cell Repertoire for Antigen & MHC

      • Ann Pullen, Edward Wakeland, Wayne Potts, John Kappler, Philippa Marrack
      Pages 199-208
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Keywords

About this book

Autoimmune diseases are common and often associated with considerable morbidity or - in diseases such as IDDM, myasthenia gravis and multiple sclerosis - mortality. In this volume, experts of international stature in basic science and clinical medicine with a common interest in understanding the normal and aberrant immune response present their experiences. It was their intention to fur- ther the understanding of potential clinical application of scientific observations and to help to comprehend the huge amount of results in autoimmunity research.

Editors and Affiliations

  • Department of Medicine, King’s College School of Medicine, London, UK

    Andrew G. Demaine, J-Paul Banga, Alan M. McGregor

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