Abstract
Insulin dependent diabetes mellitus (IDDM) is a disease with an autoimmune aetiology. The mechanism by which selective beta cell destruction occurs is not understood. Although T cells are clearly involved in the disease process it is not known whether they are effector cells directly mediating destruction via a class I or class II cytotoxic mechanism or via the production of cytokines or whether they are indirectly involved either by producing lymphokines which synergise with macrophage products in the destruction of the beta cell or by providing help for B cells to make antibody which affects beta cells by ADCC. The non obese diabetic (NOD) mouse strain and the BB rat spontaneously develop IDDM and provide excellent animal models of the human autoimmune disease (Makino et al. 1980, Nakhooda et al. 1977). These two animal models complement one another, it being easier to carry out some manipulations in the NOD e.g. genetics, while other manipulations e.g. pancreatic biopsies are easier in the BB rat.
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© 1990 Springer-Verlag Berlin Heidelberg
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O’Reilly, L. et al. (1990). Factors Affecting Diabetes in Rodent Models of Insulin Dependent Diabetes Mellitus. In: Demaine, A.G., Banga, JP., McGregor, A.M. (eds) The Molecular Biology of Autoimmune Disease. NATO ASI Series, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75133-2_29
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DOI: https://doi.org/10.1007/978-3-642-75133-2_29
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