Abstract
Approximately 70% of patients with Type I diabetes (IDDM) carry a specific HLA gene, called HLA-DQ3.2, representing one specific allele at the DQß (DQB1) locus within the HLA-D region of chromosome 6. HLA-DQ3.2 is linked to nearby HLA-DR locus genes which encode the HLA-DR4 specificity, accounting for the fact that the “DR4 type” is the most common HLA specificity associated with IDDM (Nepom, 1986). HLA-DQ3.2 is therefore an excellent candidate for a “disease susceptibility gene”, contributing to important pathogenic events in the induction or progression of autoimmunity in IDDM.
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© 1990 Springer-Verlag Berlin Heidelberg
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Nepom, G.T., Robinson, D.M. (1990). HLA-DQ and Diabetes Mellitus: A Genetic and Structural Paradigm for Models of Disease Susceptibility. In: Demaine, A.G., Banga, JP., McGregor, A.M. (eds) The Molecular Biology of Autoimmune Disease. NATO ASI Series, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75133-2_24
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DOI: https://doi.org/10.1007/978-3-642-75133-2_24
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