Abstract
Viruses have been implicated in the etiopathogenesis of many diseases of unknown origin, and in particular diseases where autoimmunity has been speculated to play a role (Mims, 1985). Several of the characteristic features of a virus infection have been proposed to enable the virus to precipitate an autoimmune response or to turn a protective immune response into a, potentially harmful, self reactive immune response. Virus may infect cells of the immune system thereby perturbing their function (McChesney and Oldstone, 1987). Thus, examples from spontaneous and experimental diseases have demonstrated that virus infection of T and/or B cells interfere with the function of these cells, in vitro and in vivo, e.g., following infection with measle and human immunodeficiency virus (HIV) and in mice lactic dehydrogenase virus infects macrophages through their Ia molecules (Inada and Mims, 1984) and may thus interfere with these cells’ antigen presenting function.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Buus s, Sette A, Colon S, Miles C, Grey HM(1987) The relationship between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides. Science 235: 1353–1358
Dale JB, Beachey EH (1985) Epitopes of streptococc¨¤l M proteins shared with cardiac myosin. J Exp Med 162: 583–591
Damian RT (1988) Parasites and molecular mimicry. In: Lernmark A, Dyrberg T, Terenius L, Hökfelt B (eds) Molecular mimicry in health and disease. Excerpta Medica, Amsterdam, New York, Oxford, p 211
Dyrberg T, Michelsen B, Oldstone M (1988) Virus and host cell antigen sharing in myasthenia gravis and autoimmune dia-betes. In: Lernmark A, Dyrberg T, Terenius L, Hökfelt B (eds) Molecular mimicry in health and disease. Excerpta Medica, Amsterdam, New York, Oxford, p 245
Fujinami RS, Nelson JA, Walker L, Oldstone MBA (1988) Sequence homology and immunologic cross-reactivity of human cytomegalovirus with HLA-DR ß chain: a means for graft rejection and immunosuppression. J Virol 62: 100–105
Fujinami RS, Oldstone MBA (1985) Amino acid homology between the encephalitogenic site of myelin basic protein and virus: mechanism for autoimmunity. Science 230: 1043–1045
Golding H, Robey FA, Gates FT III, Linder W, Beining PR, Hoffman T, Golding B (1988) Identification of homologous regions in human immunodeficiency virus I gp41 and human MHC Class II ß I domain. J Exp Med 167: 914–923
Golding H, Shearer GM, Hillman K, Lucas P, Manischewitz J, Zajac RA, Clerici M, Gress RE, Boswell RN, Golding B (1989) Common epitope in human immunodeficiency virus (HIV) I-GP41 and HLA class II elicits immunosuppressive autoantibodies capable of contributing to immune dysfunction in HIV I-infected individuals. J Clin Invest 83: 1430–1435
Horn GT, Bugawan TL, Long CM, Erlich HA (1988) Allelic sequence variation of the HLA-DQ loci: relationship to serology and to insulindependent diabetes susceptibility. Proc Natl Acad Sci USA 85: 6012–6016
Inada T, Mims C (1984) Mouse Ia antigens are receptor for lactate dehydrogenase virus. Nature 309: 59–61
McChesney MB, Oldstone MBA (1987) Viruses perturb lymphocyte functions: selected principles characterizing virus-induced immunosuppression. Ann Rev Immunol 5: 279–304
Mims CA (1985) Viral aetiology of diseases of obscure origin. Br Med Bull 41: 63–69
Oldstone, MBA (1987) Molecular mimicry and autoimmune disease. Cell 50: 819–820
Schwimmbeck PL, Dyrberg T, Drachman DB, Oldstone MBA (1989) Molecular mimicry and myasthenia gravis: an autoantigenic site of the acetylcholine receptor a subunit that has biologic activity and reacts immunochemically with herpes simplex virus. Submitted for publication
Schwimmbeck PL, Yu DTY, Oldstone MBA (1987) Autoantibodies to HLA B27 in the sera of HLA B27 patients with ankylosing spondylitis and Reiter’s syndrome. J Exp Med 166: 173–181
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1990 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Dyrberg, T. (1990). Molecular Mimicry between Virus Proteins and Autoantigens in Autoimmunity. In: Demaine, A.G., Banga, JP., McGregor, A.M. (eds) The Molecular Biology of Autoimmune Disease. NATO ASI Series, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75133-2_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-75133-2_17
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-75135-6
Online ISBN: 978-3-642-75133-2
eBook Packages: Springer Book Archive