Abstract
The accumulated evidence of the past two decades is overwhelmingly in favour of an autoimmune mechanism of beta cell destruction leading to insulin dependent (Type I diabetes mellitus. This evidence includes the association of insulin dependent diabetes with certain alleles of major histocompatibility complex genes, elevated levels of circulating activated T-cells, recapitulation of the beta cell destructive process in pancreas grafts in the absence of graft rejection, and the presence of antiislet cell auto-antibodies (Bottazzo GF, et al. 1974; MacCuish AC, et al. 1974) in the circulation of the majority of patients. It is this latter feature, anti-islet cell autoantibodies, that can be considered to be a hallmark of autoimmune diabees. While these autoantibodies have been extensively studied and have been shown to be present in individuals up to 10 years prior to development of overt diabetes. The biochemical nature of the target autoantigen(s) with which these autoantibodies react still remains to be elucidated.
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© 1990 Springer-Verlag Berlin Heidelberg
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Nayak, R.C. (1990). Glycolipid Antigens in Type I Diabetes Mellitus and Its Long Term Complications. In: Demaine, A.G., Banga, JP., McGregor, A.M. (eds) The Molecular Biology of Autoimmune Disease. NATO ASI Series, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-75133-2_13
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DOI: https://doi.org/10.1007/978-3-642-75133-2_13
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